MORF4L1 explained

Mortality factor 4-like protein 1 is a protein that in humans is encoded by the MORF4L1 gene.^{[1] [2] [3]}

Interactions

MORF4L1 has been shown to interact with MYST1,^[4] Retinoblastoma protein^{[4] [5]} and MRFAP1.^{[4] [5]}

Further reading

• Doyon Y, Côté J . The highly conserved and multifunctional NuA4 HAT complex . Current Opinion in Genetics & Development . 14 . 2 . 147–54 . Apr 2004 . 15196461 . 10.1016/j.gde.2004.02.009 .
• Pena AN, Pereira-Smith OM . The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging . Annals of the New York Academy of Sciences . 1100 . 1 . 299–305 . Apr 2007 . 17460191 . 10.1196/annals.1395.031 . 2007NYASA1100..299P . 12635963 .
• Bertram MJ, Bérubé NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barrett JC, Smith JR, Pereira-Smith OM . Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes . Molecular and Cellular Biology . 19 . 2 . 1479–85 . Feb 1999 . 9891081 . 116076 . 10.1128/mcb.19.2.1479.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Research . 10 . 10 . 1546–60 . Oct 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
• Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM . MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14 . The Journal of Biological Chemistry . 276 . 42 . 39171–8 . Oct 2001 . 11500496 . 10.1074/jbc.M103435200 . free .
• Yochum GS, Ayer DE . Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split . Molecular and Cellular Biology . 22 . 22 . 7868–76 . Nov 2002 . 12391155 . 134742 . 10.1128/MCB.22.22.7868-7876.2002 .
• Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM . MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation . The Journal of Biological Chemistry . 277 . 52 . 50860–6 . Dec 2002 . 12397079 . 10.1074/jbc.M203839200 . free .
• Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW . Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex . The Journal of Biological Chemistry . 278 . 44 . 42733–6 . Oct 2003 . 12963728 . 10.1074/jbc.C300389200 . free .
• Tominaga K, Leung JK, Rookard P, Echigo J, Smith JR, Pereira-Smith OM . MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner . The Journal of Biological Chemistry . 278 . 49 . 49618–24 . Dec 2003 . 14506250 . 10.1074/jbc.M309192200 . free .
• Doyon Y, Selleck W, Lane WS, Tan S, Côté J . Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans . Molecular and Cellular Biology . 24 . 5 . 1884–96 . Mar 2004 . 14966270 . 350560 . 10.1128/MCB.24.5.1884-1896.2004 .
• Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM . PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice . Molecular and Cellular Biology . 24 . 19 . 8366–73 . Oct 2004 . 15367658 . 516751 . 10.1128/MCB.24.19.8366-8373.2004 .
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J . Large-scale cDNA transfection screening for genes related to cancer development and progression . Proceedings of the National Academy of Sciences of the United States of America . 101 . 44 . 15724–9 . Nov 2004 . 15498874 . 524842 . 10.1073/pnas.0404089101 . 2004PNAS..10115724W . free .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . Jan 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Cai Y, Jin J, Florens L, Swanson SK, Kusch T, Li B, Workman JL, Washburn MP, Conaway RC, Conaway JW . The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes . The Journal of Biological Chemistry . 280 . 14 . 13665–70 . Apr 2005 . 15647280 . 10.1074/jbc.M500001200 . free .

Notes and References

1. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . Apr 1996 . 8619474 . 10.1006/abio.1996.0138 .
2. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . Apr 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
3. Web site: Entrez Gene: MORF4L1 mortality factor 4 like 1.
4. Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM . MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation . The Journal of Biological Chemistry . 277 . 52 . 50860–6 . Dec 2002 . 12397079 . 10.1074/jbc.M203839200 . free .
5. Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM . MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14 . The Journal of Biological Chemistry . 276 . 42 . 39171–8 . Oct 2001 . 11500496 . 10.1074/jbc.M103435200 . free .