MORC3 explained

MORC family CW-type zinc finger protein 3 is a protein that in humans is encoded by the MORC3 gene.^{[1] [2]}

This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain.^[3]

See also

• Zinc finger

Further reading

• Nagase T, Seki N, Tanaka A, etal . Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. . DNA Res. . 2 . 4 . 167–74, 199–210 . 1996 . 8590280 . 10.1093/dnares/2.4.167 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Hattori M, Fujiyama A, Taylor TD, etal . The DNA sequence of human chromosome 21. . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . 2000Natur.405..311H . free .
• Kimura Y, Sakai F, Nakano O, etal . The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains. . J. Biol. Chem. . 277 . 23 . 20611–7 . 2002 . 11927593 . 10.1074/jbc.M201440200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Rosendorff A, Sakakibara S, Lu S, etal . NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5308–13 . 2006 . 16567619 . 10.1073/pnas.0601066103 . 1459351 . 2006PNAS..103.5308R . free .
• Takahashi K, Yoshida N, Murakami N, etal . Dynamic regulation of p53 subnuclear localization and senescence by MORC3. . Mol. Biol. Cell . 18 . 5 . 1701–9 . 2007 . 17332504 . 10.1091/mbc.E06-08-0747 . 1855011 .

Notes and References

1. Perry J, Zhao Y . The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants . Trends Biochem Sci . 28 . 11 . 576–80 . Nov 2003 . 14607086 . 10.1016/j.tibs.2003.09.007 .
2. Web site: Entrez Gene: MORC3 MORC family CW-type zinc finger 3.
3. Web site: Entrez Gene: MORC3 MORC family CW-type zinc finger 3.