MOCOS explained

Molybdenum cofactor sulfurase is an enzyme that in humans is encoded by the MOCOS gene.^{[1] [2]}

MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH) and aldehyde oxidase (AOX1), which is required for their enzymatic activities.^[1]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Tuneyoshi K, Matsui K, Cheng J, Hada T . 6 . Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II . Metabolism . 52 . 11 . 1501–4 . November 2003 . 14624414 . 10.1016/s0026-0495(03)00272-5 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . October 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Peretz H, Naamati MS, Levartovsky D, Lagziel A, Shani E, Horn I, Shalev H, Landau D . 6 . Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria . Molecular Genetics and Metabolism . 91 . 1 . 23–9 . May 2007 . 17368066 . 10.1016/j.ymgme.2007.02.005 .

Notes and References

1. Ichida K, Matsumura T, Sakuma R, Hosoya T, Nishino T . Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II . Biochemical and Biophysical Research Communications . 282 . 5 . 1194–200 . April 2001 . 11302742 . 10.1006/bbrc.2001.4719 .
2. Web site: Entrez Gene: MOCOS molybdenum cofactor sulfurase.