MOAP1 explained

Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene.^{[1] [2]}

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.^[2]

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Simpson JC, Wellenreuther R, Poustka A, etal . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . free . 2002PNAS...9916899M .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Baksh S, Tommasi S, Fenton S, etal . The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. . Mol. Cell . 18 . 6 . 637–50 . 2005 . 15949439 . 10.1016/j.molcel.2005.05.010 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Vos MD, Dallol A, Eckfeld K, etal . The RASSF1A tumor suppressor activates Bax via MOAP-1. . J. Biol. Chem. . 281 . 8 . 4557–63 . 2006 . 16344548 . 10.1074/jbc.M512128200 . free .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . free .
• Fu NY, Sukumaran SK, Yu VC . Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria. . Proc. Natl. Acad. Sci. U.S.A. . 104 . 24 . 10051–6 . 2007 . 17535899 . 10.1073/pnas.0700007104 . 1877986 . 2007PNAS..10410051F . free .

Notes and References

1. Tan KO, Tan KM, Chan SL, Yee KS, Bevort M, Ang KC, Yu VC . MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains . J Biol Chem . 276 . 4 . 2802–7 . May 2001 . 11060313 . 10.1074/jbc.M008955200 . free.
2. Web site: Entrez Gene: MOAP1 modulator of apoptosis 1.