CAB39 explained

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.^[1]

The protein encoded by this gene associates with STK11 (Serine/Threonine Kinase 11) and STRAD (STE20-Related ADaptor protein).^[2] CAB39 enhances formation of STK11/STRAD complexes and stimulates STK11 catalytic activity. CAB39 may function as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization.^[2]

Further reading

• Baas AF, Smit L, Clevers H . LKB1 tumor suppressor protein: PARtaker in cell polarity . Trends Cell Biol. . 14 . 6 . 312–9 . 2004 . 15183188 . 10.1016/j.tcb.2004.04.001 .
• Hawley SA, Davison M, Woods A . Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase . J. Biol. Chem. . 271 . 44 . 27879–87 . 1996 . 8910387 . 10.1074/jbc.271.44.27879 . etal. free .
• Lai CH, Chou CY, Ch'ang LY . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 10.1101/gr.10.5.703 . 310876 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Boudeau J, Baas AF, Deak M . MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm . EMBO J. . 22 . 19 . 5102–14 . 2003 . 14517248 . 10.1093/emboj/cdg490 . 204473 . etal.
• Brajenovic M, Joberty G, Küster B . Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network . J. Biol. Chem. . 279 . 13 . 12804–11 . 2004 . 14676191 . 10.1074/jbc.M312171200 . etal. free .
• Milburn CC, Boudeau J, Deak M . Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor . Nat. Struct. Mol. Biol. . 11 . 2 . 193–200 . 2004 . 14730349 . 10.1038/nsmb716 . 18401688 . etal.
• Lizcano JM, Göransson O, Toth R . LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 . EMBO J. . 23 . 4 . 833–43 . 2005 . 14976552 . 10.1038/sj.emboj.7600110 . 381014 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Boudeau J, Scott JW, Resta N . Analysis of the LKB1-STRAD-MO25 complex . J. Cell Sci. . 117 . Pt 26 . 6365–75 . 2005 . 15561763 . 10.1242/jcs.01571 . etal. free .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Web site: Entrez Gene: CAB39 calcium binding protein 39.
2. Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR . MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm . EMBO J. . 22 . 19 . 5102–14 . October 2003 . 14517248 . 204473 . 10.1093/emboj/cdg490 .