MNT (gene) explained

MNT (Max-binding protein MNT) is a Max-binding protein that is encoded by the MNT gene^{[1] [2] [3]}

Function

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. Its delta signature is 44. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain ^{[1] [4]}

Interactions

MNT (gene) has been shown to interact with MLX,^{[5] [6]} SIN3A^[7] and MAX.^[7]

Further reading

• Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R . Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor . The EMBO Journal . 16 . 10 . 2892–2906 . May 1997 . 9184233 . 1169897 . 10.1093/emboj/16.10.2892 .
• Hirotsune S, Pack SD, Chong SS, Robbins CM, Pavan WJ, Ledbetter DH, Wynshaw-Boris A . Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region . Genome Research . 7 . 6 . 625–634 . June 1997 . 9199935 . 310661 . 10.1101/gr.7.6.625 .
• Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A . Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? . Oncogene . 19 . 29 . 3266–3277 . July 2000 . 10918583 . 10.1038/sj.onc.1203634 . free .
• Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A . WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network . Human Molecular Genetics . 10 . 6 . 617–627 . March 2001 . 11230181 . 10.1093/hmg/10.6.617 . free .
• Stoneley M, Spencer JP, Wright SC . An internal ribosome entry segment in the 5' untranslated region of the mnt gene . Oncogene . 20 . 7 . 893–897 . February 2001 . 11314024 . 10.1038/sj.onc.1204157 . free .
• Dintilhac A, Bernués J . HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences . The Journal of Biological Chemistry . 277 . 9 . 7021–7028 . March 2002 . 11748221 . 10.1074/jbc.M108417200 . free . free . 10261/112516 .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–716 . June 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Smith AG, Popov N, Imreh M, Axelson H, Henriksson M . Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells . Journal of Cellular Biochemistry . 92 . 6 . 1282–1295 . August 2004 . 15258910 . 10.1002/jcb.20121 . 35885353 .
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS . Transcriptome analysis of human gastric cancer . Mammalian Genome . 16 . 12 . 942–954 . December 2005 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 .
• Guo XL, Pan L, Zhang XJ, Suo XH, Niu ZY, Zhang JY, Wang F, Dong ZR, Da W, Ohno R . Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia . Leukemia & Lymphoma . 48 . 6 . 1200–1207 . June 2007 . 17577784 . 10.1080/10428190701342018 . 24127330 .

Notes and References

1. Hurlin PJ, Quéva C, Eisenman RN . Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites . Genes & Development . 11 . 1 . 44–58 . January 1997 . 9000049 . 10.1101/gad.11.1.44 . free .
2. Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R . The human ROX gene: genomic structure and mutation analysis in human breast tumors . Genomics . 49 . 2 . 275–282 . April 1998 . 9598315 . 10.1006/geno.1998.5241 .
3. Web site: Entrez Gene: MNT MAX binding protein.
4. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R . Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor . The EMBO Journal . 16 . 10 . 2892–2906 . May 1997 . 9184233 . 1169897 . 10.1093/emboj/16.10.2892 .
5. Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A . WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network . Human Molecular Genetics . 10 . 6 . 617–627 . March 2001 . 11230181 . 10.1093/hmg/10.6.617 . free .
6. Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A . Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? . Oncogene . 19 . 29 . 3266–3277 . July 2000 . 10918583 . 10.1038/sj.onc.1203634 . free .
7. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R . Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor . The EMBO Journal . 16 . 10 . 2892–2906 . May 1997 . 9184233 . 1169897 . 10.1093/emboj/16.10.2892 .