MMPIP explained

MMPIP is a drug used in scientific research that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR7.[1] This receptor subtype appears to be involved in the downstream response to cocaine in the brain.[2]

Notes and References

  1. Suzuki G, Tsukamoto N, Fushiki H, Kawagishi A, Nakamura M, Kurihara H, Mitsuya M, Ohkubo M, Ohta H . In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists . The Journal of Pharmacology and Experimental Therapeutics . 323 . 1 . 147–56 . October 2007 . 17609420 . 10.1124/jpet.107.124701 . 10402176 .
  2. Li X, Li J, Peng XQ, Spiller K, Gardner EL, Xi ZX . Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism . Neuropsychopharmacology . 34 . 7 . 1783–96 . June 2009 . 19158667 . 10.1038/npp.2008.236 . 3739975 .

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