MMP24 explained

Matrix metalloproteinase-24 is an enzyme that in humans is encoded by the MMP24 gene.^{[1] [2]}

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24.^[2]

Further reading

• Nagase H, Woessner JF . Matrix metalloproteinases. . J. Biol. Chem. . 274 . 31 . 21491–4 . 1999 . 10419448 . 10.1074/jbc.274.31.21491 . free .
• Kinoh H, Hayashita H, Kajita M, etal . Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2→q12, respectively, by radiation hybrid and in situ hybridization. . Cytogenet. Cell Genet. . 87 . 1–2 . 97–8 . 2000 . 10640822 . 10.1159/000015402 . 24060884 .
• Romanic AM, Burns-Kurtis CL, Ao Z, etal . Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients. . Am. J. Physiol. Renal Physiol. . 281 . 2 . F309–17 . 2001 . 11457723 . 10.1152/ajprenal.2001.281.2.F309. 5735565 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Jung M, Römer A, Keyszer G, etal . mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue. . Prostate . 55 . 2 . 89–98 . 2003 . 12661033 . 10.1002/pros.10194 . 21596144 .
• Takino T, Koshikawa N, Miyamori H, etal . Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. . Oncogene . 22 . 30 . 4617–26 . 2003 . 12879005 . 10.1038/sj.onc.1206542 . 2297/2668 . 10007952 . free .
• Wang P, Wang X, Pei D . Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV. . J. Biol. Chem. . 279 . 19 . 20461–70 . 2004 . 14990567 . 10.1074/jbc.M400264200 . free .
• Gaetje R, Holtrich U, Engels K, etal . Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis. . Gynecol. Endocrinol. . 23 . 10 . 567–73 . 2008 . 17952761 . 10.1080/09513590701556921 . 25621136 .

Notes and References

1. Llano E, Pendas AM, Freije JP, Nakano A, Knauper V, Murphy G, Lopez-Otin C . Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors . Cancer Res . 59 . 11 . 2570–6 . Jun 1999 . 10363975 .
2. Web site: Entrez Gene: MMP24 matrix metallopeptidase 24 (membrane-inserted).