MMP23B explained

Matrix metalloproteinase-23 is an enzyme that in humans is encoded by the MMP23B gene.[1] [2] [3]

Function

This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the copy of the duplicated region of the gene that is closer to the end of the chromosome (more telemeric).

MMP23B is strongly expressed in ovary and heart.[4]

Further reading

External links

Notes and References

  1. Gururajan R, Grenet J, Lahti JM, Kidd VJ . Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3 . Genomics . 52 . 1 . 101–6 . May 1999 . 9740677 . 10.1006/geno.1998.5401 .
  2. Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF, Kidd VJ . Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2 . Genome Res . 8 . 9 . 929–39 . Nov 1998 . 9750192 . 310781 . 10.1101/gr.8.9.929.
  3. Web site: Entrez Gene: MMP23B matrix metallopeptidase 23B.
  4. Zhao S, Zhao Y, Niu P, Wang N, Tang Z, Zan L, Li K . Molecular characterization of porcine MMP19 and MMP23B genes and its association with immune traits . Int. J. Biol. Sci. . 7 . 8 . 1101–13 . 2011 . 21927579 . 10.7150/ijbs.7.1101 . 3174387.