MMP11 explained

Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene.^{[1] [2] [3] [4]}

Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.^[4]

Further reading

• Nagase H, Woessner JF . Matrix metalloproteinases. . J. Biol. Chem. . 274 . 31 . 21491–4 . 1999 . 10419448 . 10.1074/jbc.274.31.21491 . free .
• Basset P, Bellocq JP, Wolf C, etal . A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. . Nature . 348 . 6303 . 699–704 . 1991 . 1701851 . 10.1038/348699a0 . 4233952 .
• Pei D, Majmudar G, Weiss SJ . Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3. . J. Biol. Chem. . 269 . 41 . 25849–55 . 1994 . 10.1016/S0021-9258(18)47324-3 . 7523394 . free .
• Pei D, Weiss SJ . Furin-dependent intracellular activation of the human stromelysin-3 zymogen. . Nature . 375 . 6528 . 244–7 . 1995 . 7746327 . 10.1038/375244a0 . 1995Natur.375..244P . 2027.42/62522 . 4266100 . free .
• Boulay A, Masson R, Chenard MP, etal . High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3 matrix metalloproteinase. . Cancer Res. . 61 . 5 . 2189–93 . 2001 . 11280785 .
• Perret AG, Duthel R, Fotso MJ, etal . Stromelysin-3 is expressed by aggressive meningiomas. . Cancer . 94 . 3 . 765–72 . 2002 . 11857311 . 10.1002/cncr.10270 . 26088137 .
• Nakopoulou L, Panayotopoulou EG, Giannopoulou I, etal . Stromelysin-3 protein expression in invasive breast cancer: relation to proliferation, cell survival and patients' outcome. . Mod. Pathol. . 15 . 11 . 1154–61 . 2003 . 12429794 . 10.1097/01.MP.0000037317.84782.CD . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Wasenius VM, Hemmer S, Kettunen E, etal . Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study. . Clin. Cancer Res. . 9 . 1 . 68–75 . 2003 . 12538453 .
• Fromigué O, Louis K, Wu E, etal . Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase. . Int. J. Cancer . 106 . 3 . 355–63 . 2003 . 12845673 . 10.1002/ijc.11232 . 27594080 . free .
• Skoglund J, Emterling A, Arbman G, etal . Clinicopathological significance of stromelysin-3 expression in colorectal cancer. . Oncology . 67 . 1 . 67–72 . 2004 . 15459498 . 10.1159/000080288 . 23298126 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Louis K, Guérineau N, Fromigué O, etal . Tumor cell-mediated induction of the stromal factor stromelysin-3 requires heterotypic cell contact-dependent activation of specific protein kinase C isoforms. . J. Biol. Chem. . 280 . 2 . 1272–83 . 2005 . 15509588 . 10.1074/jbc.M405482200 . free .
• Deng H, Guo RF, Li WM, etal . Matrix metalloproteinase 11 depletion inhibits cell proliferation in gastric cancer cells. . Biochem. Biophys. Res. Commun. . 326 . 2 . 274–81 . 2005 . 15582574 . 10.1016/j.bbrc.2004.11.027 .
• Arora S, Kaur J, Sharma C, etal . Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: correlation with microvessel density, progression, and prognosis. . Clin. Cancer Res. . 11 . 6 . 2272–84 . 2005 . 15788677 . 10.1158/1078-0432.CCR-04-0572 . free .
• Vazquez-Ortiz G, Pina-Sanchez P, Vazquez K, etal . Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer. . BMC Cancer . 5 . 68 . 2006 . 15989693 . 10.1186/1471-2407-5-68 . 1175083 . free .

Notes and References

1. Levy A, Zucman J, Delattre O, Mattei MG, Rio MC, Basset P . Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22 . Genomics . 13 . 3 . 881–3 . Aug 1992 . 1639418 . 10.1016/0888-7543(92)90175-R .
2. Anglard P, Melot T, Guerin E, Thomas G, Basset P . Structure and promoter characterization of the human stromelysin-3 gene . J Biol Chem . 270 . 35 . 20337–44 . Oct 1995 . 7657606 . 10.1074/jbc.270.35.20337 . free .
3. Luo D, Mari B, Stoll I, Anglard P . Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase . J Biol Chem . 277 . 28 . 25527–36 . Jul 2002 . 12006591 . 10.1074/jbc.M202494200 . free .
4. Web site: Entrez Gene: MMP11 matrix metallopeptidase 11 (stromelysin 3).