MMP10 explained

Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an enzyme that in humans is encoded by the MMP10 gene.^{[1] [2]}

Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.^[3]

Clinical significance

MMP10 has been linked to cancer stem cell vitality and metastasis.^[4]

MMP10 is a potential prognostic biomarker for oral cancer.^[5]

Further reading

• Chandler S, Miller KM, Clements JM, Lury J, Corkill D, Anthony DC, Adams SE, Gearing AJ . Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview . Journal of Neuroimmunology . 72 . 2 . 155–61 . February 1997 . 9042108 . 10.1016/S0165-5728(96)00179-8 . 26495949 .
• Nagase H, Woessner JF . Matrix metalloproteinases . The Journal of Biological Chemistry . 274 . 31 . 21491–4 . July 1999 . 10419448 . 10.1074/jbc.274.31.21491 . free .
• Fosang AJ, Neame PJ, Hardingham TE, Murphy G, Hamilton JA . Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins . The Journal of Biological Chemistry . 266 . 24 . 15579–82 . August 1991 . 10.1016/S0021-9258(18)98442-5 . 1874716 . free .
• Sirum KL, Brinckerhoff CE . Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts . Biochemistry . 28 . 22 . 8691–8 . October 1989 . 2605216 . 10.1021/bi00448a004 .
• Lichtinghagen R, Helmbrecht T, Arndt B, Böker KH . Expression pattern of matrix metalloproteinases in human liver . European Journal of Clinical Chemistry and Clinical Biochemistry . 33 . 2 . 65–71 . February 1995 . 7632822 . 10.1515/cclm.1995.33.2.65 . 10.1.1.633.9185 . 34999090 .
• Nguyen Q, Murphy G, Hughes CE, Mort JS, Roughley PJ . Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein . The Biochemical Journal . 295 . Pt 2 . 595–8 . October 1993 . 7694569 . 1134922 . 10.1042/bj2950595.
• Conca W, Willmroth F . Human T lymphocytes express a member of the Matrix Metalloproteinase gene family . Arthritis and Rheumatism . 37 . 6 . 951–6 . June 1994 . 8003069 . 10.1002/art.1780370626 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Gack S, Vallon R, Schaper J, Rüther U, Angel P . Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein . The Journal of Biological Chemistry . 269 . 14 . 10363–9 . April 1994 . 10.1016/S0021-9258(17)34069-3 . 8144618 . free .
• Windsor LJ, Grenett H, Birkedal-Hansen B, Bodden MK, Engler JA, Birkedal-Hansen H . Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters . The Journal of Biological Chemistry . 268 . 23 . 17341–7 . August 1993 . 10.1016/S0021-9258(19)85340-1 . 8349617 . free .
• Knäuper V, Murphy G, Tschesche H . Activation of human neutrophil procollagenase by stromelysin 2 . European Journal of Biochemistry . 235 . 1–2 . 187–91 . January 1996 . 8631328 . 10.1111/j.1432-1033.1996.00187.x .
• Pendás AM, Santamaría I, Alvarez MV, Pritchard M, López-Otín C . Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3 . Genomics . 37 . 2 . 266–8 . October 1996 . 8921407 . 10.1006/geno.1996.0557 .
• Sorsa T, Salo T, Koivunen E, Tyynelä J, Konttinen YT, Bergmann U, Tuuttila A, Niemi E, Teronen O, Heikkilä P, Tschesche H, Leinonen J, Osman S, Stenman UH . Activation of type IV procollagenases by human tumor-associated trypsin-2 . The Journal of Biological Chemistry . 272 . 34 . 21067–74 . August 1997 . 9261109 . 10.1074/jbc.272.34.21067 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Madlener M, Werner S . cDNA cloning and expression of the gene encoding murine stromelysin-2 (MMP-10) . Gene . 202 . 1–2 . 75–81 . November 1997 . 9427548 . 10.1016/S0378-1119(97)00456-3 .
• Nakamura H, Fujii Y, Ohuchi E, Yamamoto E, Okada Y . Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases . European Journal of Biochemistry . 253 . 1 . 67–75 . April 1998 . 9578462 . 10.1046/j.1432-1327.1998.2530067.x . free .
• Bord S, Horner A, Hembry RM, Compston JE . Stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) expression in developing human bone: potential roles in skeletal development . Bone . 23 . 1 . 7–12 . July 1998 . 9662124 . 10.1016/S8756-3282(98)00064-7 .

External links

• The MEROPS online database for peptidases and their inhibitors: M10.006

Notes and References

1. Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R . The collagenase gene family in humans consists of at least four members . The Biochemical Journal . 253 . 1 . 187–92 . July 1988 . 2844164 . 1149273 . 10.1042/bj2530187.
2. Jung JY, Warter S, Rumpler Y . Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization . Annales de Génétique . 33 . 1 . 21–3 . 1990 . 2369069 .
3. Web site: Entrez Gene: MMP10 matrix metallopeptidase 10 (stromelysin 2).
4. Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP . Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential . PLOS ONE . 7 . 4 . e35040 . 2012 . 22545096 . 3335833 . 10.1371/journal.pone.0035040 . 2012PLoSO...735040J . free .
5. Upadhyay P, Gardi N, Desai S, Chandrani P, Joshi A, Dharavath B, Arora P, Bal M, Nair S, Dutt A . Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases . Oral Oncology . 73 . 56–64 . 2017 . 28939077 . 5628952 . 10.1016/j.oraloncology.2017.08.003 .