MMAI explained

5-Methoxy-6-methyl-2-aminoindane (MMAI) is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University.[1] It acts as a non-neurotoxic and highly selective serotonin releasing agent (SSRA) and produces entactogen effects in humans.[1] [2] [3] [4] It has been sold as a designer drug and research chemical online since 2010.

MMAI has been shown to relieve stress-induced depression in rats more robustly than sertraline,[5] and as a result it has been suggested that SSRAs like MMAI and 4-MTA could be developed as novel antidepressants with a faster onset of therapeutic action and superior efficacy to current antidepressants such as the selective serotonin reuptake inhibitors (SSRIs).[6]

Notes and References

  1. Marona-Lewicka D, Nichols DE . Behavioral effects of the highly selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindan . European Journal of Pharmacology . 258 . 1–2 . 1–13 . June 1994 . 7925587 . 10.1016/0014-2999(94)90051-5 . 10.1.1.688.1895 .
  2. Li Q, Murakami I, Stall S, Levy AD, Brownfield MS, Nichols DE, Van de Kar LD . Neuroendocrine pharmacology of three serotonin releasers: 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butane (MBDB), 5-methoxy-6-methyl-2-aminoindan (MMAi) and p-methylthioamphetamine (MTA) . The Journal of Pharmacology and Experimental Therapeutics . 279 . 3 . 1261–1267 . December 1996 . 8968349 .
  3. Rudnick G, Wall SC . Non-neurotoxic amphetamine derivatives release serotonin through serotonin transporters . Molecular Pharmacology . 43 . 2 . 271–276 . February 1993 . 8429828 .
  4. Luethi D, Kolaczynska KE, Docci L, Krähenbühl S, Hoener MC, Liechti ME . Pharmacological profile of mephedrone analogs and related new psychoactive substances . Neuropharmacology . 134 . Pt A . 4–12 . May 2018 . 28755886 . 10.1016/j.neuropharm.2017.07.026 . 28786127 .
  5. Marona-Lewicka D, Nichols DE . The Effect of Selective Serotonin Releasing Agents in the Chronic Mild Stress Model of Depression in Rats . Stress . 2 . 2 . 91–100 . December 1997 . 9787258 . 10.3109/10253899709014740 .
  6. Scorza C, Silveira R, Nichols DE, Reyes-Parada M . Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action . Neuropharmacology . 38 . 7 . 1055–1061 . July 1999 . 10428424 . 10.1016/S0028-3908(99)00023-4 . 13714807 .

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