MLLT10 explained

Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene.^{[1] [2]}

Interactions

MLLT10 has been shown to interact with SS18.^[3]

Further reading

• Silliman CC, McGavran L, Wei Q, Miller LA, Li S, Hunger SP . Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides . Leukemia . 12 . 9 . 1404–10 . 1998 . 9737689 . 10.1038/sj.leu.2401109 . 5821466 .
• Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V . Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation . J. Mol. Biol. . 299 . 2 . 369–78 . 2000 . 10860745 . 10.1006/jmbi.2000.3766 .
• Lillington DM, Jaju RJ, Shankar AG, Neat M, Kearney L, Young BD, Saha V . Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia . Br. J. Haematol. . 110 . 3 . 547–51 . 2000 . 10997963 . 10.1046/j.1365-2141.2000.02212.x . 45898713 . free .
• de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A . The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10 . Oncogene . 20 . 25 . 3281–9 . 2001 . 11423977 . 10.1038/sj.onc.1204419 . 2364045 .
• Debernardi S, Bassini A, Jones LK, Chaplin T, Linder B, de Bruijn DR, Meese E, Young BD . The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex . Blood . 99 . 1 . 275–81 . 2002 . 11756182 . 10.1182/blood.V99.1.275 . free .
• Cai Y, Gao Y, Sheng Q, Miao S, Cui X, Wang L, Zong S, Koide SS . Characterization and potential function of a novel testis-specific nucleoporin BS-63 . Mol. Reprod. Dev. . 61 . 1 . 126–34 . 2002 . 11774384 . 10.1002/mrd.1139 . 23631919 .
• Roll P, Zattara-Cannoni H, Bustos-Bernard MC, Curtillet C, Michel G, Vagner-Capodano AM . Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia . Cancer Genet. Cytogenet. . 135 . 2 . 187–91 . 2002 . 12127405 . 10.1016/S0165-4608(01)00644-6 .
• Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E . ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation . Mol. Cell . 10 . 5 . 1119–28 . 2002 . 12453419 . 10.1016/S1097-2765(02)00740-2 . free .
• Perrin L, Bloyer S, Ferraz C, Agrawal N, Sinha P, Dura JM . The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions . Mol. Cell. Biol. . 23 . 1 . 119–30 . 2003 . 12482966 . 140655 . 10.1128/MCB.23.1.119-130.2003 .
• Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y . hDOT1L links histone methylation to leukemogenesis . Cell . 121 . 2 . 167–78 . 2005 . 15851025 . 10.1016/j.cell.2005.02.020 . 15638573 . free .

Notes and References

1. Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD . A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia . Blood . 85 . 6 . 1435–41 . Apr 1995 . 7888665 . 10.1182/blood.V85.6.1435.bloodjournal8561435. free .
2. Web site: Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10.
3. de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A . The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10 . Oncogene . 20 . 25 . 3281–9 . May 2001 . 11423977 . 10.1038/sj.onc.1204419 . 2364045 .