MLLT1 explained

Protein ENL is a protein that in humans is encoded by the MLLT1 gene.^[1]

Interactions

MLLT1 has been shown to interact with CBX8.^[2]

Further reading

• Tkachuk DC, Kohler S, Cleary ML . Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias . Cell . 71 . 4 . 691–700 . November 1992 . 1423624 . 10.1016/0092-8674(92)90602-9 . 11801536 .
• Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD . Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia . Proceedings of the National Academy of Sciences of the United States of America . 91 . 25 . 12110–4 . December 1994 . 7991593 . 45386 . 10.1073/pnas.91.25.12110 . 1994PNAS...9112110T . free .
• Rubnitz JE, Morrissey J, Savage PA, Cleary ML . ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells . Blood . 84 . 6 . 1747–52 . September 1994 . 8080983 . 10.1182/blood.V84.6.1747.1747. free .
• Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T . Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia . Oncogene . 8 . 10 . 2617–25 . October 1993 . 8378076 .
• Lavau C, Luo RT, Du C, Thirman MJ . Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice . Proceedings of the National Academy of Sciences of the United States of America . 97 . 20 . 10984–9 . September 2000 . 10995463 . 27135 . 10.1073/pnas.190167297 . 2000PNAS...9710984L . free .
• García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK . The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3 . Oncogene . 20 . 4 . 411–9 . January 2001 . 11313972 . 10.1038/sj.onc.1204108 . free .
• Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W . Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner . Molecular and Cellular Biology . 23 . 8 . 2942–52 . April 2003 . 12665591 . 152562 . 10.1128/MCB.23.8.2942-2952.2003 .
• Gué M, Sun JS, Boudier T . Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited . BMC Cancer . 6 . 20 . January 2006 . 16433901 . 1388228 . 10.1186/1471-2407-6-20 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Meyer C, Burmeister T, Strehl S, Schneider B, Hubert D, Zach O, Haas O, Klingebiel T, Dingermann T, Marschalek R . Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia . Leukemia . 21 . 3 . 588–90 . March 2007 . 17252016 . 10.1038/sj.leu.2404542 . 34843802 .

Notes and References

1. Web site: Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1.
2. García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK . The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3 . Oncogene . 20 . 4 . 411–9 . January 2001 . 11313972 . 10.1038/sj.onc.1204108 . free .