MKNK2 explained

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.^{[1] [2]}

Interactions

MNK2 has been shown to interact with MAPK1^{[3] [4]} and Eukaryotic translation initiation factor 4 gamma.^[3]

MNK2 has been identified as a therapeutic target for diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote beta cell regeneration.^[5]

Further reading

• Haribabu B, Snyderman R . Identification of additional members of human G-protein-coupled receptor kinase multigene family . Proceedings of the National Academy of Sciences of the United States of America . 90 . 20 . 9398–9402 . October 1993 . 8415712 . 47575 . 10.1073/pnas.90.20.9398 . free . 1993PNAS...90.9398H .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Waskiewicz AJ, Flynn A, Proud CG, Cooper JA . Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 . The EMBO Journal . 16 . 8 . 1909–1920 . April 1997 . 9155017 . 1169794 . 10.1093/emboj/16.8.1909 .
• Scheper GC, Morrice NA, Kleijn M, Proud CG . The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells . Molecular and Cellular Biology . 21 . 3 . 743–754 . February 2001 . 11154262 . 86666 . 10.1128/MCB.21.3.743-754.2001 .
• Knauf U, Tschopp C, Gram H . Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2 . Molecular and Cellular Biology . 21 . 16 . 5500–5511 . August 2001 . 11463832 . 87272 . 10.1128/MCB.21.16.5500-5511.2001 .
• Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG . The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization . Molecular and Cellular Biology . 23 . 16 . 5692–5705 . August 2003 . 12897141 . 166352 . 10.1128/MCB.23.16.5692-5705.2003 .
• Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL . Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway . Journal of Virology . 79 . 17 . 11366–11381 . September 2005 . 16103188 . 1193619 . 10.1128/JVI.79.17.11366-11381.2005 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . October 2005 . 16189514 . 10.1038/nature04209 . 4427026 . 2005Natur.437.1173R .
• Jauch R, Jäkel S, Netter C, Schreiter K, Aicher B, Jäckle H, Wahl MC . Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site . Structure . 13 . 10 . 1559–1568 . October 2005 . 16216586 . 10.1016/j.str.2005.07.013 . free . 11858/00-001M-0000-0010-9408-D .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . 6 . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Wang P, Wang X, Wang F, Cai T, Luo Y . Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex . Science in China Series C: Life Sciences . 49 . 3 . 265–273 . June 2006 . 16856496 . 10.1007/s11427-006-0265-5 . 23339861 .

Notes and References

1. Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP . Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta . Genomics . 69 . 1 . 63–71 . October 2000 . 11013076 . 10.1006/geno.2000.6299 .
2. Web site: Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2.
3. Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG . The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization . Molecular and Cellular Biology . 23 . 16 . 5692–5705 . August 2003 . 12897141 . 166352 . 10.1128/MCB.23.16.5692-5705.2003 .
4. Waskiewicz AJ, Flynn A, Proud CG, Cooper JA . Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 . The EMBO Journal . 16 . 8 . 1909–1920 . April 1997 . 9155017 . 1169794 . 10.1093/emboj/16.8.1909 .
5. Karampelias C, Watt K, Mattsson CL, Ruiz ÁF, Rezanejad H, Mi J, Liu X, Chu L, Locasale JW, Korbutt GS, Rovira M, Larsson O, Andersson O . 6 . MNK2 deficiency potentiates β-cell regeneration via translational regulation . Nature Chemical Biology . 18 . 9 . 942–953 . September 2022 . 35697798 . 10.1038/s41589-022-01047-x . 7613404 .