MKNK1 explained

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.^{[1] [2]}

Interactions

MKNK1 has been shown to interact with MAPK1^[3] and Eukaryotic translation initiation factor 4 gamma.^[4]

Further reading

• de Carvalho MG, McCormack AL, Olson E, etal . Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes. . J. Biol. Chem. . 271 . 12 . 6987–97 . 1996 . 8636128 . 10.1074/jbc.271.12.6987 . free .
• Waskiewicz AJ, Flynn A, Proud CG, Cooper JA . Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. . EMBO J. . 16 . 8 . 1909–20 . 1997 . 9155017 . 10.1093/emboj/16.8.1909 . 1169794 .
• Börsch-Haubold AG, Bartoli F, Asselin J, etal . Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. . J. Biol. Chem. . 273 . 8 . 4449–58 . 1998 . 9468497 . 10.1074/jbc.273.8.4449 . free .
• Pyronnet S, Imataka H, Gingras AC, etal . Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. . EMBO J. . 18 . 1 . 270–9 . 1999 . 9878069 . 10.1093/emboj/18.1.270 . 1171121 .
• Waskiewicz AJ, Johnson JC, Penn B, etal . Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. . Mol. Cell. Biol. . 19 . 3 . 1871–80 . 1999 . 10022874 . 10.1128/MCB.19.3.1871. 83980 .
• Cuesta R, Laroia G, Schneider RJ . Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes. . Genes Dev. . 14 . 12 . 1460–70 . 2000 . 10.1101/gad.14.12.1460 . 10859165 . 316692 .
• Hefner Y, Borsch-Haubold AG, Murakami M, etal . Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases. . J. Biol. Chem. . 275 . 48 . 37542–51 . 2001 . 10978317 . 10.1074/jbc.M003395200 . free .
• Scheper GC, Morrice NA, Kleijn M, Proud CG . The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. . Mol. Cell. Biol. . 21 . 3 . 743–54 . 2001 . 11154262 . 10.1128/MCB.21.3.743-754.2001 . 86666 .
• Knauf U, Tschopp C, Gram H . Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. . Mol. Cell. Biol. . 21 . 16 . 5500–11 . 2001 . 11463832 . 10.1128/MCB.21.16.5500-5511.2001 . 87272 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Reuter TY, Medhurst AL, Waisfisz Q, etal . Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. . Exp. Cell Res. . 289 . 2 . 211–21 . 2003 . 14499622 . 10.1016/S0014-4827(03)00261-1 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Cuesta R, Xi Q, Schneider RJ . Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein. . J. Virol. . 78 . 14 . 7707–16 . 2004 . 15220445 . 10.1128/JVI.78.14.7707-7716.2004 . 434077 .
• Orton KC, Ling J, Waskiewicz AJ, etal . Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. . J. Biol. Chem. . 279 . 37 . 38649–57 . 2004 . 15234964 . 10.1074/jbc.M407337200 . free .
• O'Loghlen A, González VM, Piñeiro D, etal . Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. . Exp. Cell Res. . 299 . 2 . 343–55 . 2004 . 15350534 . 10.1016/j.yexcr.2004.06.006 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Worch J, Tickenbrock L, Schwäble J, etal . The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells. . Oncogene . 23 . 57 . 9162–72 . 2005 . 15516979 . 10.1038/sj.onc.1208164 . 25123414 .
• Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC . Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells. . J. Biol. Chem. . 280 . 6 . 4772–8 . 2005 . 15563472 . 10.1074/jbc.M408356200 . free.
• O'Loghlen A, González VM, Salinas M, Martín ME . Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T cells. . FEBS Lett. . 578 . 1–2 . 31–5 . 2005 . 15581611 . 10.1016/j.febslet.2004.10.063 . 28489044 .

Notes and References

1. Fukunaga R, Hunter T . MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates . EMBO J . 16 . 8 . 1921–33 . Jun 1997 . 9155018 . 1169795 . 10.1093/emboj/16.8.1921 .
2. Web site: Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1.
3. Waskiewicz . A J . Flynn A . Proud C G . Cooper J A . Apr 1997 . Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 . EMBO J. . 16 . 8 . 1909–20 . ENGLAND. 0261-4189. 9155017 . 10.1093/emboj/16.8.1909 . 1169794 .
4. Pyronnet . S . Imataka H . Gingras A C . Fukunaga R . Hunter T . Sonenberg N . Jan 1999 . Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E . EMBO J. . 18 . 1 . 270–9 . ENGLAND. 0261-4189. 9878069 . 10.1093/emboj/18.1.270 . 1171121 .