MKL2 explained

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene.^{[1] [2]}

Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation, motile function ^[3] and addiction. ^[4]

Further reading

• Nakajima D, Okazaki N, Yamakawa H, etal . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Wang DZ, Li S, Hockemeyer D, etal . Potentiation of serum response factor activity by a family of myocardin-related transcription factors. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 23 . 14855–60 . 2003 . 12397177 . 10.1073/pnas.222561499 . 137508 . free . 2002PNAS...9914855W .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Cen B, Selvaraj A, Burgess RC, etal . Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. . Mol. Cell. Biol. . 23 . 18 . 6597–608 . 2003 . 12944485 . 10.1128/MCB.23.18.6597-6608.2003 . 193697 .
• Selvaraj A, Prywes R . Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. . J. Biol. Chem. . 278 . 43 . 41977–87 . 2004 . 14565952 . 10.1074/jbc.M305679200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Morita T, Mayanagi T, Sobue K . Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. . J. Cell Biol. . 179 . 5 . 1027–42 . 2007 . 18056415 . 10.1083/jcb.200708174 . 2099179 .

Notes and References

1. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 6 . 5 . 337–45 . Jan 2000 . 10574462 . 10.1093/dnares/6.5.337 . free .
2. Web site: Entrez Gene: MKL2 MKL/myocardin-like 2.
3. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O . Emerging roles of the myocardin family of proteins in lipid and glucose metabolism . J Physiol . 594 . 17 . 4741–4752 . September 2016 . 27060572 . 5009794 . 10.1113/JP271913 .
4. Ariza A, Funahashi Y, Kozawa S, Faruk MO, Nagai T, Amano M, Kaibuchi K . Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK . Journal of Neurochemistry . 2021 . 157 . 6 . 1774–1788 . 33449379 . 10.1111/jnc.15303. 231613803 .