MK-212 explained

MK-212 (CPP or 6-chloro-2-(1-piperazinyl)pyrazine)^[1] is a serotonin agonist.^[2] It promotes the secretion of serum prolactin and cortisol in humans.^[3]

Pharmacology

In an experiment performed by Clineschidt and colleagues, they dosed mice with varying concentrations of MK-212, and observed its effects.^[4] The result correlated very well to binding of indolealkylamine receptors, such as the serotonin and tryptamine receptors, which shows four characteristics. Namely, increased frequency of muscle twitching, increased twitching of the head,^[5] "an increase in the strength of the crossed extensor reflex in the acutely spinalized rat", and the cause of complex motor syndrome.

See also

• 2C-B-PP
• mCPP
• ORG-12962
• Quipazine

Notes and References

1. Clineschidmt BV . MK-212: a serotonin-like agonist in the CNS . General Pharmacology . 10 . 4 . 287–90 . 1979 . 488663 . 10.1016/0306-3623(79)90054-5 .
2. Bastani B, Nash JF, Meltzer HY . Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder . Archives of General Psychiatry . 47 . 9 . 833–9 . September 1990 . 2203327 . 10.1001/archpsyc.1990.01810210041006 .
3. Lowy MT, Meltzer HY . Stimulation of serum cortisol and prolactin secretion in humans by MK-212, a centrally active serotonin agonist . Biological Psychiatry . 23 . 8 . 818–28 . April 1988 . 3365458 . 10.1016/0006-3223(88)90070-4 . 32736259 .
4. Clineschmidt BV, Mcguffin JC, Pflueger AB . Central serotonin-like activity of 6-chloro-2-[1-piperazinyl]-pyrazine (CPP; MK-212) . European Journal of Pharmacology . 44 . 1 . 65–74 . July 1977 . 885160 . 10.1016/0014-2999(77)90117-0 .
5. Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ . 6 . Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells . British Journal of Pharmacology . 128 . 1 . 13–20 . September 1999 . 10498829 . 1571597 . 10.1038/sj.bjp.0702751 .