MIZF explained

Histone H4 transcription factor is a protein that in humans is encoded by the HINFP gene.^{[1] [2]}

Function

HINFP is a protein that binds to a highly conserved DNA motif found in most histone H4 genes. HINFP activates H4 gene expression through interactions with the CDK2 substrate NPAT which is localized in Histone Locus Bodies. HINFP was independently described as a protein called "MBD2 interacting zinc finger protein" (MIZF). MIZF was reported to interact with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex. MIZF is thought to play a role in DNA methylation and transcription repression.[supplied by OMIM]^[3]

Interactions

One key partner protein of HINFP is NPAT, a CDK2 substrate that localizes to Histone Locus Bodies. MIZF has been reported to interact with Methyl-CpG-binding domain protein 2 and DHX9.^[4]

Further reading

• Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS . The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes . Cancer Res. . 67 . 21 . 10334–42 . 2007 . 17974976 . 10.1158/0008-5472.CAN-07-1560 .
• Mitra P, Xie R, Harper JW, Stein JL, Stein GS, van Wijnen AJ . HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription . J. Cell. Biochem. . 101 . 1 . 181–91 . 2007 . 17163457 . 10.1002/jcb.21157 . 23552843 .
• Fukushige S, Kondo E, Gu Z, Suzuki H, Horii A . RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression . Biochem. Biophys. Res. Commun. . 351 . 1 . 85–92 . 2006 . 17049487 . 10.1016/j.bbrc.2006.10.005 .
• Pulukuri SM, Rao JS . CpG island promoter methylation and silencing of 14-3-3sigma gene expression in LNCaP and Tramp-C1 prostate cancer cell lines is associated with methyl-CpG-binding protein MBD2 . Oncogene . 25 . 33 . 4559–72 . 2006 . 16786000 . 1526774 . 10.1038/sj.onc.1209462 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Miele A, Braastad CD, Holmes WF, Mitra P, Medina R, Xie R, Zaidi SK, Ye X, Wei Y, Harper JW, van Wijnen AJ, Stein JL, Stein GS . HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition . Mol. Cell. Biol. . 25 . 14 . 6140–53 . 2005 . 15988025 . 1168814 . 10.1128/MCB.25.14.6140-6153.2005 .
• Sekimata M, Homma Y . Regulation of Rb gene expression by an MBD2-interacting zinc finger protein MIZF during myogenic differentiation . Biochem. Biophys. Res. Commun. . 325 . 3 . 653–9 . 2004 . 15541338 . 10.1016/j.bbrc.2004.10.090 .
• Sekimata M, Homma Y . Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF . Nucleic Acids Res. . 32 . 2 . 590–7 . 2004 . 14752047 . 373363 . 10.1093/nar/gkh249 .
• Mitra P, Xie RL, Medina R, Hovhannisyan H, Zaidi SK, Wei Y, Harper JW, Stein JL, van Wijnen AJ, Stein GS . Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase . Mol. Cell. Biol. . 23 . 22 . 8110–23 . 2003 . 14585971 . 262391 . 10.1128/MCB.23.22.8110-8123.2003 .

Notes and References

1. Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y . Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2 . J. Biol. Chem. . 276 . 46 . 42632–8 . Nov 2001 . 11553631 . 10.1074/jbc.M107048200 . free .
2. Web site: Entrez Gene: MIZF MBD2-interacting zinc finger.
3. Web site: Entrez Gene: MIZF MBD2-interacting zinc finger.
4. Fujita H, Fujii R, Aratani S, Amano T, Fukamizu A, Nakajima T . Antithetic effects of MBD2a on gene regulation . Mol. Cell. Biol. . 23 . 8 . 2645–57 . Apr 2003 . 12665568 . 152551 . 10.1128/MCB.23.8.2645-2657.2003 .