MIR7-1 explained

MicroRNA 7-1 is a microRNA molecule that in humans is encoded by the MIR7-1 gene.^[1]

Function

microRNAs, or miRNAs, are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

• Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP . Vertebrate microRNA genes . Science . 299 . 5612 . 1540 . March 2003 . 12624257 . 10.1126/science.1080372 . 37750545 .
• Correa-Medina M, Bravo-Egana V, Rosero S, Ricordi C, Edlund H, Diez J, Pastori RL . MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas . Gene Expression Patterns . 9 . 4 . 193–9 . April 2009 . 19135553 . 10.1016/j.gep.2008.12.003 .
• Chen AX, Yu KD, Fan L, Li JY, Yang C, Huang AJ, Shao ZM . Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility . PLOS Genetics . 7 . 9 . e1002259 . September 2011 . 21912531 . 3164678 . 10.1371/journal.pgen.1002259 . Horwitz . Marshall S . free .
• Xu L, Wen Z, Zhou Y, Liu Z, Li Q, Fei G, Luo J, Ren T . MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway . Molecular Biology of the Cell . 24 . 1 . 42–55 . January 2013 . 23135998 . 3530778 . 10.1091/mbc.E12-07-0519 .
• Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B . microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma . Cancer Research . 68 . 10 . 3566–72 . May 2008 . 18483236 . 10.1158/0008-5472.CAN-07-6639 . free .
• Bravo-Egana V, Rosero S, Molano RD, Pileggi A, Ricordi C, Domínguez-Bendala J, Pastori RL . Quantitative differential expression analysis reveals miR-7 as major islet microRNA . Biochemical and Biophysical Research Communications . 366 . 4 . 922–6 . February 2008 . 18086561 . 4104201 . 10.1016/j.bbrc.2007.12.052 .
• Chen ZX, Sun AM, Chen Y, Liu Y, Zhan JF, Chen LH, Yuan YW . [Effects of radiosensitivity and X-ray dose on miR-7 expression in nasopharyngeal carcinoma] . Nan Fang Yi Ke da Xue Xue Bao = Journal of Southern Medical University . 30 . 8 . 1810–2, 1816 . August 2010 . 20813671 .
• Kredo-Russo S, Ness A, Mandelbaum AD, Walker MD, Hornstein E . Regulation of pancreatic microRNA-7 expression . Experimental Diabetes Research . 2012 . 695214 . 2012 . 22675342 . 3362837 . 10.1155/2012/695214 . free .
• Wang Y, Liu J, Liu C, Naji A, Stoffers DA . MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells . Diabetes . 62 . 3 . 887–95 . March 2013 . 23223022 . 3581216 . 10.2337/db12-0451 .
• Midgley AC, Bowen T, Phillips AO, Steadman R . MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts . Aging Cell . 13 . 2 . 235–44 . April 2014 . 24134702 . 4331777 . 10.1111/acel.12167 .
• Midgley AC, Morris G, Phillips AO, Steadman R . 17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation . Aging Cell . 15 . 3 . 531–41 . June 2016 . 26931423 . 4854905 . 10.1111/acel.12462 .

Notes and References

1. Web site: Entrez Gene: MicroRNA 7-1 . . . 26 December 2013 .