Multiple inositol-polyphosphate phosphatase explained

multiple inositol-polyphosphate phosphatase
Ec Number:	3.1.3.62
Cas Number:	116958-30-6
Go Code:	0004446

The enzyme multiple inositol-polyphosphate phosphatase (EC 3.1.3.62) catalyzes the reaction

myo-inositol hexakisphosphate + H₂O

\rightleftharpoons myo-inositol pentakisphosphate (mixed isomers) + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase. Other names in common use include inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase, inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase, inositol tetrakisphosphate phosphomonoesterase, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase, and MIPP. This enzyme participates in inositol phosphate metabolism.

References

• Cullen PJ, Irvine RF, Drobak BK, Dawson AP . 1989 . Inositol 1,3,4,5-tetrakisphosphate causes release of Ca²⁺ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate . Biochem. J. . 259 . 931 - 3 . 2786415 . 3 . 1138610 .
• Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB . Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase . Biochem. J. . 328 . 75 - 81 . 9359836 . 1218889 .