MIER1 explained

Mesoderm induction early response protein 1 is a protein that in humans is encoded by the MIER1 gene.^{[1] [2] [3]}

Interactions

MIER1 has been shown to interact with HDAC1.^[2]

Further reading

• Paterno GD, Mercer FC, Chayter JJ, Yang X, Robb JD, Gillespie LL . Molecular cloning of human er1 cDNA and its differential expression in breast tumours and tumour-derived cell lines . Gene . 222 . 1 . 77–82 . Nov 1998 . 9813250 . 10.1016/S0378-1119(98)00473-9 .
• Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 7 . 4 . 273–81 . Aug 2000 . 10997877 . 10.1093/dnares/7.4.271 . free .
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S . Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways . Oncogene . 22 . 21 . 3307–18 . May 2003 . 12761501 . 10.1038/sj.onc.1206406 . free .
• Ding Z, Gillespie LL, Mercer FC, Paterno GD . The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter . The Journal of Biological Chemistry . 279 . 27 . 28009–16 . Jul 2004 . 15117948 . 10.1074/jbc.M403793200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R . Phosphoproteome analysis of the human mitotic spindle . Proceedings of the National Academy of Sciences of the United States of America . 103 . 14 . 5391–6 . Apr 2006 . 16565220 . 1459365 . 10.1073/pnas.0507066103 . 2006PNAS..103.5391N . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Paterno GD, Ding Z, Lew YY, Nash GW, Mercer FC, Gillespie LL . Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization . Gene . 295 . 1 . 79–88 . Jul 2002 . 12242014 . 10.1016/S0378-1119(02)00823-5 .
2. Ding Z, Gillespie LL, Paterno GD . Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain . Molecular and Cellular Biology . 23 . 1 . 250–8 . Jan 2003 . 12482978 . 140656 . 10.1128/MCB.23.1.250-258.2003 .
3. Web site: Entrez Gene: MIER1 mesoderm induction early response 1 homolog (Xenopus laevis).