MHC class I polypeptide–related sequence B explained

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus.^[1] MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. MICB is a stress-induced ligand for NKG2D receptor.^[2] The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.^[3]

See also

• MICA

Further reading

• Braud VM, Allan DS, McMichael AJ . Functions of nonclassical MHC and non-MHC-encoded class I molecules . Current Opinion in Immunology . 11 . 1 . 100–8 . Feb 1999 . 10047540 . 10.1016/S0952-7915(99)80018-1 .
• Borrego F, Kabat J, Kim DK, Lieto L, Maasho K, Peña J, Solana R, Coligan JE . Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells . Molecular Immunology . 38 . 9 . 637–60 . Feb 2002 . 11858820 . 10.1016/S0161-5890(01)00107-9 .
• Leelayuwat C, Townend DC, Degli-Esposti MA, Abraham LJ, Dawkins RL . A new polymorphic and multicopy MHC gene family related to nonmammalian class I . Immunogenetics . 40 . 5 . 339–51 . 1994 . 7927538 . 10.1007/BF01246675 . 10504768 .
• Bahram S, Spies T . Nucleotide sequence of a human MHC class I MICB cDNA . Immunogenetics . 43 . 4 . 230–3 . 1996 . 8575823 . 10.1007/BF00587305 .
• Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM . Genes in a 220-kb region spanning the TNF cluster in human MHC . Genomics . 31 . 2 . 215–22 . Jan 1996 . 8824804 . 10.1006/geno.1996.0034 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T . Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium . Proceedings of the National Academy of Sciences of the United States of America . 93 . 22 . 12445–50 . Oct 1996 . 8901601 . 38011 . 10.1073/pnas.93.22.12445 . 1996PNAS...9312445G . free .
• Bahram S, Shiina T, Oka A, Tamiya G, Inoko H . Genomic structure of the human MHC class I MICB gene . Immunogenetics . 45 . 2 . 161–2 . 1997 . 8952966 . 10.1007/s002510050184 . 26270690 .
• Gaudieri S, Leelayuwat C, Townend DC, Mullberg J, Cosman D, Dawkins RL . Allelic and interlocus comparison of the PERB11 multigene family in the MHC . Immunogenetics . 45 . 3 . 209–16 . 1997 . 8995188 . 10.1007/s002510050191 . 6658841 .
• Pellet P, Renaud M, Fodil N, Laloux L, Inoko H, Hauptmann G, Debré P, Bahram S, Theodorou I . Allelic repertoire of the human MICB gene . Immunogenetics . 46 . 5 . 434–6 . 1997 . 9271635 . 10.1007/s002510050299 . 7799593 .
• Ando H, Mizuki N, Ota M, Yamazaki M, Ohno S, Goto K, Miyata Y, Wakisaka K, Bahram S, Inoko H . Allelic variants of the human MHC class I chain-related B gene (MICB) . Immunogenetics . 46 . 6 . 499–508 . 1997 . 9321430 . 10.1007/s002510050311 . 1912407 .
• Groh V, Steinle A, Bauer S, Spies T . Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells . Science . 279 . 5357 . 1737–40 . Mar 1998 . 9497295 . 10.1126/science.279.5357.1737 .
• Visser CJ, Tilanus MG, Schaeffer V, Tatari Z, Tamouza R, Janin A, Charron D . Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles . Tissue Antigens . 51 . 6 . 649–52 . Jun 1998 . 9694358 . 10.1111/j.1399-0039.1998.tb03008.x . free .
• Steinle A, Groh V, Spies T . Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules . Proceedings of the National Academy of Sciences of the United States of America . 95 . 21 . 12510–5 . Oct 1998 . 9770516 . 22861 . 10.1073/pnas.95.21.12510 . 1998PNAS...9512510S . free .
• Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T . Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB . Proceedings of the National Academy of Sciences of the United States of America . 96 . 12 . 6879–84 . Jun 1999 . 10359807 . 22010 . 10.1073/pnas.96.12.6879 . 1999PNAS...96.6879G . free .
• Tay GK, Hui J, Gaudieri S, Schmitt-Egenolf M, Martinez OP, Leelayuwat C, Williamson JF, Eiermann TH, Dawkins RL . PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis . Clinical and Experimental Immunology . 119 . 3 . 553–8 . Mar 2000 . 10691930 . 1905592 . 10.1046/j.1365-2249.2000.01140.x .
• Fischer G, Pérez-Rodríguez M, Argüello JR, Cox ST, McWhinnie A, Travers PJ, Madrigal JA . Three novel MICB alleles . Tissue Antigens . 55 . 2 . 166–70 . Feb 2000 . 10746790 . 10.1034/j.1399-0039.2000.550210.x . free .
• Cerwenka A, Bakker AB, McClanahan T, Wagner J, Wu J, Phillips JH, Lanier LL . Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice . Immunity . 12 . 6 . 721–7 . Jun 2000 . 10894171 . 10.1016/S1074-7613(00)80222-8 . free .

Notes and References

1. Bahram S, Bresnahan M, Geraghty DE, Spies T . A second lineage of mammalian major histocompatibility complex class I genes . Proceedings of the National Academy of Sciences of the United States of America . 91 . 14 . 6259–63 . Jul 1994 . 8022771 . 44180 . 10.1073/pnas.91.14.6259 . 1994PNAS...91.6259B . free .
2. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T . Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA . Science . 285 . 5428 . 727–9 . Jul 1999 . 10426993 . 10.1126/science.285.5428.727 .
3. Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T . Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium . Proceedings of the National Academy of Sciences of the United States of America . 93 . 22 . 12445–50 . Oct 1996 . 8901601 . 10.1073/pnas.93.22.12445 . 38011. 1996PNAS...9312445G . free .