MICAL3 explained

Microtubule-associated monoxygenase, calponin and LIM domain containing 3, also known as MICAL3, is a human gene.^[1]

Function

Along with two other Rab proteins, Rab6 and Rab8, MICAL3 work together in the process of docking and fusing of vesicles that are involved in exocytosis.^[2]

Further reading

• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 5 . 6 . 355–364 . December 1998 . 10048485 . 10.1093/dnares/5.6.355 . free .
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–495 . December 1999 . 10591208 . 10.1038/990031 . free . 1999Natur.402..489D .
• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 7 . 1 . 65–73 . February 2000 . 10718198 . 10.1093/dnares/7.1.65 . free .
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proceedings of the National Academy of Sciences of the United States of America . 97 . 7 . 3491–3496 . March 2000 . 10737800 . 16267 . 10.1073/pnas.97.7.3491 . free . 2000PNAS...97.3491D .
• Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL . MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion . Cell . 109 . 7 . 887–900 . June 2002 . 12110185 . 10.1016/S0092-8674(02)00794-8 . free .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–716 . June 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–12135 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . free . 2004PNAS..10112130B .
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I . A genome annotation-driven approach to cloning the human ORFeome . Genome Biology . 5 . 10 . R84 . 2005 . 15461802 . 545604 . 10.1186/gb-2004-5-10-r84 . free .
• Fischer J, Weide T, Barnekow A . The MICAL proteins and rab1: a possible link to the cytoskeleton? . Biochemical and Biophysical Research Communications . 328 . 2 . 415–423 . March 2005 . 15694364 . 10.1016/j.bbrc.2004.12.182 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .

Notes and References

1. Web site: Entrez Gene: MICAL3 microtubule associated monoxygenase, calponin and LIM domain containing 3.
2. Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, Demmers J, Peränen J, Pasterkamp RJ, van der Sluijs P, Hoogenraad CC, Akhmanova A . Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers . Current Biology . 21 . 11 . 967–974 . June 2011 . 21596566 . 10.1016/j.cub.2011.04.030 . 7950950 . free . 2011CBio...21..967G .