MGST3 explained

Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.^{[1] [2]}

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.

Further reading

• Jakobsson PJ, Morgenstern R, Mancini J, etal . Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily. . Am. J. Respir. Crit. Care Med. . 161 . 2 Pt 2 . S20–4 . 2000 . 10673221 . 10.1164/ajrccm.161.supplement_1.ltta-5.
• Kobayashi K, Xin Y, Ymer SI, etal . Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells. . Brain Res. . 1170 . 129–39 . 2007. 17719568 . 10.1016/j.brainres.2007.07.042 . 31320196 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Thameem F, Yang X, Permana PA, etal . Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians. . Hum. Genet. . 113 . 4 . 353–8 . 2003 . 12898215 . 10.1007/s00439-003-0980-y . 105953 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW . Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities . J Biol Chem . 272 . 36 . 22934–9 . Oct 1997 . 9278457 . 10.1074/jbc.272.36.22934 . free .
2. Web site: Entrez Gene: MGST3 microsomal glutathione S-transferase 3.