MGAT5B explained

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT5B gene.^{[1] [2] [3]}

Further reading

• Land A, Braakman I . Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum . Biochimie . 83 . 8 . 783–790 . 2001 . 11530211 . 10.1016/S0300-9084(01)01314-1 . 1874/5091 . 13576808 . free .
• Abbott KL, Troupe K, Lee I, Pierce M . Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb . Exp. Cell Res. . 312 . 15 . 2837–2850 . 2006 . 16857188 . 10.1016/j.yexcr.2006.05.022 .
• Lee I . N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen . J. Neurochem. . 97 . 4 . 947–956 . 2006 . 16606368 . 10.1111/j.1471-4159.2006.03785.x . vanc. Guo HB . Kamar M . 3 . Abbott . Karen . Troupe . Karolyn . Lee . Jin-Kyu . Alvarez-Manilla . Gerardo . Pierce . Michael . 22339355 . free .
• Inamori K . Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain . Biochim. Biophys. Acta . 1760 . 4 . 678–684 . 2006 . 16413118 . 10.1016/j.bbagen.2005.11.019 . vanc. Mita S . Gu J . 3 . Mizunohorikawa . Y . Miyoshi . E . Dennis . J . Taniguchi . N .
• Guo HB, Lee I, Kamar M, Pierce M . N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways . J. Biol. Chem. . 278 . 52 . 52412–52424 . 2004 . 14561752 . 10.1074/jbc.M308837200 . free .
• Inamori K . Molecular cloning and characterization of human GnT-IX, a novel beta1,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain . J. Biol. Chem. . 278 . 44 . 43102–43109 . 2003 . 12941944 . 10.1074/jbc.M308255200 . vanc. Endo T . Ide Y . 3 . Fujii . S . Gu . J . Honke . K . Taniguchi . N . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Papandreou MJ, Fenouillet E . Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation . FEBS Lett. . 406 . 1–2 . 191–195 . 1997 . 9109416 . 10.1016/S0014-5793(97)00273-1 . 17660 . free .
• Bolmstedt A . Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response . J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. . 12 . 3 . 213–20 . 1996 . 8673525 . 10.1097/00042560-199607000-00001 . vanc. Sjölander S . Hansen JE . 3 . Akerblom . L . Hemming . A . Hu . SL . Morein . B . Olofsson . S . free .
• Fenouillet E . Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain . J. Virol. . 67 . 1 . 150–60 . 1993 . 8093218 . 10.1128/jvi.67.1.150-160.1993. 237347 . vanc. Jones I . Powell B . 3 . Schmitt . D . Kieny . MP . Gluckman . JC .
• Montefiori DC, Robinson WE, Mitchell WM . Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1 . Proc. Natl. Acad. Sci. U.S.A. . 85 . 23 . 9248–9252 . 1988 . 3264072 . 10.1073/pnas.85.23.9248 . 282716 . 1988PNAS...85.9248M . free .
• Blough HA . Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins . Biochem. Biophys. Res. Commun. . 141 . 1 . 33–38 . 1987 . 3099781 . 10.1016/S0006-291X(86)80330-8 . vanc. Pauwels R . De Clercq E . 3 . Cogniaux . J . Sprechergoldberger . S . Thiry . L .
• Robinson WE, Montefiori DC, Mitchell WM . Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis . AIDS Res. Hum. Retroviruses . 3 . 3 . 265–282 . 1988 . 2829950 . 10.1089/aid.1987.3.265 .
• Kozarsky K . Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein . J. Acquir. Immune Defic. Syndr. . 2 . 2 . 163–9 . 1989 . 2649653 . vanc. Penman M . Basiripour L . 3 . Haseltine . W . Sodroski . J . Krieger . M .
• Pal R, Hoke GM, Sarngadharan MG . Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1 . Proc. Natl. Acad. Sci. U.S.A. . 86 . 9 . 3384–3388 . 1989 . 2541446 . 10.1073/pnas.86.9.3384 . 287137 . 1989PNAS...86.3384P . free .
• Kalyanaraman VS . Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1 . AIDS Res. Hum. Retroviruses . 6 . 3 . 371–380 . 1990 . 2187500 . 10.1089/aid.1990.6.371 . vanc. Rodriguez V . Veronese F . 3 . Rahman . R. . Lusso . P. . Devico . A.L. . Copeland . T. . Oroszlan . S. . Gallo . R.C. .
• Dedera DA, Gu RL, Ratner L . Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function . Virology . 187 . 1 . 377–382 . 1992 . 1736542 . 10.1016/0042-6822(92)90331-I .

Notes and References

1. Inamori K, Endo T, Gu J, Matsuo I, Ito Y, Fujii S, Iwasaki H, Narimatsu H, Miyoshi E, Honke K, Taniguchi N . N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan . J Biol Chem . 279 . 4 . 2337–2340 . Jan 2004 . 14617637 . 10.1074/jbc.C300480200 . free .
2. Kaneko M, Alvarez-Manilla G, Kamar M, Lee I, Lee JK, Troupe K, Zhang W, Osawa M, Pierce M . A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB)(1) . FEBS Lett . 554 . 3 . 515–519 . Nov 2003 . 14623122 . 10.1016/S0014-5793(03)01234-1 . 82207739 . free .
3. Web site: Entrez Gene: MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B.