MGAT5 explained

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 gene.^{[1] [2]}

This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.

Further reading

• Dennis JW, Granovsky M, Warren CE . Glycoprotein glycosylation and cancer progression. . Biochim. Biophys. Acta . 1473 . 1 . 21–34 . 2000 . 10580127 . 10.1016/s0304-4165(99)00167-1.
• Buckhaults P, Chen L, Fregien N, Pierce M . Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene. . J. Biol. Chem. . 272 . 31 . 19575–81 . 1997 . 9235963 . 10.1074/jbc.272.31.19575 . free .
• Park C, Jin UH, Lee YC, etal . Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B. . Arch. Biochem. Biophys. . 367 . 2 . 281–8 . 1999 . 10395745 . 10.1006/abbi.1999.1252 .
• Granovsky M, Fata J, Pawling J, etal . Suppression of tumor growth and metastasis in Mgat5-deficient mice. . Nat. Med. . 6 . 3 . 306–12 . 2000 . 10700233 . 10.1038/73163 . 1950342 .
• Ihara S, Miyoshi E, Ko JH, etal . Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching. . J. Biol. Chem. . 277 . 19 . 16960–7 . 2002 . 11864986 . 10.1074/jbc.M200673200 . free.
• Saito T, Miyoshi E, Sasai K, etal . A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity. . J. Biol. Chem. . 277 . 19 . 17002–8 . 2002 . 11872751 . 10.1074/jbc.M200521200 . free .
• Dosaka-Akita H, Miyoshi E, Suzuki O, etal . Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers. . Clin. Cancer Res. . 10 . 5 . 1773–9 . 2004 . 15014031 . 10.1158/1078-0432.CCR-1047-3 . 14246685 .
• Guo P, Zhang Y, Shen ZH, etal . Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases. . FEBS Lett. . 562 . 1–3 . 93–8 . 2004 . 15044007 . 10.1016/S0014-5793(04)00188-7 . 42049140 . free .
• Kim CH . Increased expression of N-acetylglucosaminyltransferase-V in human hepatoma cells by retinoic acid and 1alpha,25-dihydroxyvitamin D3. . Int. J. Biochem. Cell Biol. . 36 . 11 . 2307–19 . 2005 . 15313475 . 10.1016/j.biocel.2004.04.021 .
• Tomiie M, Isaka S, Miyoshi E, etal . Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta. . Biochem. Biophys. Res. Commun. . 330 . 3 . 999–1004 . 2005 . 15809094 . 10.1016/j.bbrc.2005.02.186 .
• Fang H, Huang W, Xu YY, etal . Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7,721 cells. . Cell Res. . 16 . 1 . 82–92 . 2006 . 16467879 . 10.1038/sj.cr.7310011 . free .
• Ishimura H, Takahashi T, Nakagawa H, etal . N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer. . Clin. Cancer Res. . 12 . 8 . 2506–11 . 2006 . 16638859 . 10.1158/1078-0432.CCR-05-1938 . free .
• Wang L, Liang Y, Li Z, etal . Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721. . J. Cell. Biochem. . 100 . 1 . 230–41 . 2007 . 16924681 . 10.1002/jcb.21071 . 11808116 . free .
• Li J, Wang XM, Wang Q, etal . Down-regulation of N-acetylglucosaminyltransferase-V induces ER stress by changing glycosylation and function of GLUT1. . Arch. Biochem. Biophys. . 463 . 1 . 102–9 . 2007 . 17451637 . 10.1016/j.abb.2007.03.005 .
• Kudo T, Nakagawa H, Takahashi M, etal . N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. . Mol. Cancer . 6 . 1. 32 . 2007 . 17488527 . 10.1186/1476-4598-6-32 . 1878497 . free .

Notes and References

1. Saito H, Nishikawa A, Gu J, Ihara Y, Soejima H, Wada Y, Sekiya C, Niikawa N, Taniguchi N . cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+ . Biochem Biophys Res Commun . 198 . 1 . 318–27 . Feb 1994 . 8292036 . 10.1006/bbrc.1994.1045 .
2. Web site: Entrez Gene: MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase.