MFSD5 explained

Major facilitator superfamily domain containing 5 is an atypical SLC expressed in neuronal plasma membrane.^[1] It is a plausible Solute carrier transporter.^[2] It transports molybdate anions,^[3] and it interacts with GLP-1R.^[4]

MFSD5 belongs to AMTF6.^[5]

Notes and References

1. Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R . The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis . PLOS ONE . 11 . 6 . e0156912 . 2016 . 27272503 . 4896477 . 10.1371/journal.pone.0156912 . free . 2016PLoSO..1156912P .
2. Perland E, Fredriksson R . Classification Systems of Secondary Active Transporters . Trends in Pharmacological Sciences . 38 . 3 . 305–315 . March 2017 . 27939446 . 10.1016/j.tips.2016.11.008 .
3. Tejada-Jiménez M, Galván A, Fernández E . Algae and humans share a molybdate transporter . Proceedings of the National Academy of Sciences of the United States of America . 108 . 16 . 6420–6425 . April 2011 . 21464289 . 3080982 . 10.1073/pnas.1100700108 . free . 2011PNAS..108.6420T .
4. Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, Kittanakom S, Wong V, Wei L, Showalter AD, Sloop KW, Stagljar I, Wheeler MB . 6 . The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity . Molecular Endocrinology . 27 . 9 . 1550–1563 . September 2013 . 23864651 . 5415235 . 10.1210/me.2013-1047 .
5. Perland E, Bagchi S, Klaesson A, Fredriksson R . Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression . Open Biology . 7 . 9 . 170142 . September 2017 . 28878041 . 5627054 . 10.1098/rsob.170142 .