MFAP5 explained

Microfibrillar-associated protein 5 is a protein that in humans is encoded by the MFAP5 gene.^{[1] [2] [3]}

This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2.

Further reading

• Miyamoto A . Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation . J. Biol. Chem. . 281 . 15 . 10089–97 . 2006 . 16492672 . 10.1074/jbc.M600298200 . vanc . Lau R . Hein PW . 3 . Shipley . JM . Weinmaster . G . free.
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R.
• Imabayashi H . Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis . Exp. Cell Res. . 288 . 1 . 35–50 . 2003 . 12878157 . 10.1016/S0014-4827(03)00130-7 . vanc . Mori T . Gojo S . 3 . Kiyono . T . Sugiyama . T . Irie . R . Isogai . T . Hata . J . Toyama . Y.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free.
• Penner AS, Rock MJ, Kielty CM, Shipley JM . Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly . J. Biol. Chem. . 277 . 38 . 35044–9 . 2002 . 12122015 . 10.1074/jbc.M206363200 . free.
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free.

Notes and References

1. Hatzinikolas G, Gibson MA . The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region . J Biol Chem . 273 . 45 . 29309–14 . Dec 1998 . 9792630 . 10.1074/jbc.273.45.29309 . free .
2. Gibson MA, Hatzinikolas G, Kumaratilake JS, Sandberg LB, Nicholl JK, Sutherland GR, Cleary EG . Grant Robert Sutherland . Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25) . J Biol Chem . 271 . 2 . 1096–103 . Feb 1996 . 8557636 . 10.1074/jbc.271.2.1096 . free .
3. Web site: Entrez Gene: MFAP5 microfibrillar associated protein 5.