MFAP2 explained

Microfibrillar-associated protein 2 is a protein that in humans is encoded by the MFAP2 gene.^{[1] [2]}

Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. This gene encodes two transcripts with two alternatively spliced 5' untranslated exons. These two transcripts contain the same eight coding exons, and therefore, encode the same protein.^[2]

Further reading

• Gibson MA, Hughes JL, Fanning JC, Cleary EG . The major antigen of elastin-associated microfibrils is a 31-kDa glycoprotein. . J. Biol. Chem. . 261 . 24 . 11429–36 . 1986 . 10.1016/S0021-9258(18)67403-4 . 3015971 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Brown-Augsburger P, Broekelmann T, Rosenbloom J, Mecham RP . Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly. . Biochem. J. . 318 . 1. 149–55 . 1996 . 8761465 . 10.1042/bj3180149. 1217601 .
• Finnis ML, Gibson MA . Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen. . J. Biol. Chem. . 272 . 36 . 22817–23 . 1997 . 9278443 . 10.1074/jbc.272.36.22817 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Fujimoto N, Tajima S, Ishibashi A . Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes. . Arch. Dermatol. Res. . 292 . 1 . 21–6 . 2000 . 10664011 . 10.1007/PL00007456 . 36505268 .
• Trask BC, Broekelmann T, Ritty TM, etal . Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1). . Biochemistry . 40 . 14 . 4372–80 . 2001 . 11284693 . 10.1021/bi002738z . 10.1.1.721.7743 .
• Jensen SA, Reinhardt DP, Gibson MA, Weiss AS . Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1. . J. Biol. Chem. . 276 . 43 . 39661–6 . 2001 . 11481325 . 10.1074/jbc.M104533200 . free .
• Reinboth B, Hanssen E, Cleary EG, Gibson MA . Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1. . J. Biol. Chem. . 277 . 6 . 3950–7 . 2002 . 11723132 . 10.1074/jbc.M109540200 . free .
• Segade F, Trask BC, Broekelmann TJ, etal . Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms. . J. Biol. Chem. . 277 . 13 . 11050–7 . 2002 . 11796718 . 10.1074/jbc.M110347200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Werneck CC, Trask BC, Broekelmann TJ, etal . Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2. . J. Biol. Chem. . 279 . 22 . 23045–51 . 2004 . 15044481 . 10.1074/jbc.M402656200 . free .
• Clarke AW, Weiss AS . Microfibril-associated glycoprotein-1 binding to tropoelastin: multiple binding sites and the role of divalent cations. . Eur. J. Biochem. . 271 . 14 . 3085–90 . 2004 . 15233806 . 10.1111/j.1432-1033.2004.04246.x . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Miyamoto A, Lau R, Hein PW, etal . Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. . J. Biol. Chem. . 281 . 15 . 10089–97 . 2006 . 16492672 . 10.1074/jbc.M600298200 . free .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .

Notes and References

1. Faraco J, Bashir M, Rosenbloom J, Francke U . Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170 . Genomics . 25 . 3 . 630–7 . Jun 1995 . 7759096 . 10.1016/0888-7543(95)80004-6 . free .
2. Web site: Entrez Gene: MFAP2 microfibrillar-associated protein 2.