MEX3D explained
Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.[1] [2]
Function
MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.[2]
Structure
MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs (KH domain) and a RING domain at the C-terminus.[2]
Further reading
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
- Buchet-Poyau K, Courchet J, Le Hir H, etal . Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. . Nucleic Acids Res. . 35 . 4 . 1289–300 . 2007 . 17267406 . 10.1093/nar/gkm016 . 1851655.
Notes and References
- Web site: Entrez Gene: mex-3 homolog D (C. elegans).
- Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N . Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein . J. Biol. Chem. . 279 . 19 . 20154–66 . May 2004 . 14769789 . 10.1074/jbc.M314071200 . free .
