METRNL explained

Meteorin-like/Meteorin-Beta (Metrnl)/IL-41, also known as subfatin and cometin, is a small (~27kDa) secreted cytokine, protein encoded by a gene called meteorin-like (METRNL).[1]

Lower serum levels of Metrnl might be a risk factor for developing coronary artery disease and type 2 diabetes mellitus[2] [3]

Notes and References

  1. Rao RR, Long JZ, White JP etal . Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis . Cell . 157 . 6. 1279–1291 . 2015 . 24906147 . 10.1016/j.cell.2014.03.065 . 4131287 .
  2. Dadmanesh M, Aghajani H, Fadaei R, Ghorban K (2018) Lower serum levels of Meteorin-like/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines. PLoS ONE 13(9): e0204180.
  3. Liu, Z. X., Ji, H. H., Yao, M. P., Wang, L., Wang, Y., Zhou, P., ... & Gao, W. (2019). Serum Metrnl is associated with the presence and severity of coronary artery disease. Journal of cellular and molecular medicine, 23(1), 271-280.

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