METAP1 explained

Methionine aminopeptidase 1 is an enzyme that in humans is encoded by the METAP1 gene.^{[1] [2] [3]}

Further reading

• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Serero A, Giglione C, Sardini A, etal . An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway. . J. Biol. Chem. . 278 . 52 . 52953–63 . 2004 . 14532271 . 10.1074/jbc.M309770200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rush J, Moritz A, Lee KA, etal . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Addlagatta A, Hu X, Liu JO, Matthews BW . Structural basis for the functional differences between type I and type II human methionine aminopeptidases. . Biochemistry . 44 . 45 . 14741–9 . 2006 . 16274222 . 10.1021/bi051691k .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Selvakumar P, Lakshmikuttyamma A, Dimmock JR, Sharma RK . Methionine aminopeptidase 2 and cancer. . Biochim. Biophys. Acta . 1765 . 2 . 148–54 . 2006 . 16386852 . 10.1016/j.bbcan.2005.11.001 .
• Hu X, Addlagatta A, Lu J, etal . Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 48 . 18148–53 . 2007 . 17114291 . 10.1073/pnas.0608389103 . 1838721 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Methionine aminopeptidase 1

Notes and References

1. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res . 2 . 1 . 37–43 . Jul 1995 . 7788527 . 10.1093/dnares/2.1.37 . etal. free .
2. Dummitt B, Fei Y, Chang YH . Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae . Protein Pept Lett . 9 . 4 . 295–303 . Jul 2002 . 12144506 . 10.2174/0929866023408607 .
3. Web site: Entrez Gene: METAP1 methionyl aminopeptidase 1.