MESP1 explained

Mesoderm posterior 1 homolog (mouse) is a protein that in humans is encoded by the MESP1 gene.^[1] MESP1 is a transcription factor that regulates cardiovascular progenitor specification.^[2]

Further reading

• David R, Brenner C, Stieber J, Schwarz F, Brunner S, Vollmer M, Mentele E, Müller-Höcker J, Kitajima S, Lickert H, Rupp R, Franz WM . MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling . Nature Cell Biology . 10 . 3 . 338–45 . March 2008 . 18297060 . 10.1038/ncb1696 . 205286617 .
• Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ . Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors . Proceedings of the National Academy of Sciences of the United States of America . 109 . 32 . 13016–21 . August 2012 . 22826236 . 3420197 . 10.1073/pnas.1120299109 . 2012PNAS..10913016I . free .
• Saga Y, Hata N, Kobayashi S, Magnuson T, Seldin MF, Taketo MM . MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation . Development . 122 . 9 . 2769–78 . September 1996 . 10.1242/dev.122.9.2769 . 8787751 .
• Haraguchi S, Kitajima S, Takagi A, Takeda H, Inoue T, Saga Y . Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development . Mechanisms of Development . 108 . 1–2 . 59–69 . October 2001 . 11578861 . 10.1016/S0925-4773(01)00478-6 . free .

Notes and References

1. Web site: Entrez Gene: Mesoderm posterior 1 homolog (mouse) .
2. Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, Kyba M, Blanpain C . Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification . en . Cell Stem Cell . 3 . 1 . 69–84 . July 2008 . 18593560 . 10.1016/j.stem.2008.06.009 . free .