Mepirapim Explained

MEPIRAPIM is an indole-based cannabinoid which differs from JWH-018 by having a 4-methylpiperazine group in place of the naphthyl group^[1] and has been used as an active ingredient in synthetic cannabis products. It was first identified in Japan in 2013, alongside FUBIMINA.^[2] MEPIRAPIM acts as a T-type calcium channel inhibitor and is only minimally active at the central CB1 receptor.^[3]

Legality

Sweden's public health agency suggested to classify MEPIRAPIM as hazardous substance on November 10, 2014.^[4]

See also

• APICA
• AM-2201
• JWH-073
• JWH-250
• JWH-200
• List of JWH cannabinoids
• List of AM cannabinoids
• THJ-2201

Notes and References

1. Web site: MEPIRAPIM . Cayman Chemical . 23 June 2015.
2. Two new synthetic cannabinoids, AM-2201 benzimidazole analog (FUBIMINA) and (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone (MEPIRAPIM), and three phenethylamine derivatives, 25H-NBOMe 3,4,5-trimethoxybenzyl analog, 25B-NBOMe, and 2C-N-NBOMe, identified in illegal products . Forensic Toxicology . Uchiyama N, Shimokawa Y, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y . January 2014 . 32 . 1 . 105–115 . 10.1007/s11419-013-0217-2. 32599561 .
3. Kevin RC, Mirlohi S, Manning JJ, Boyd R, Cairns EA, Ametovski A, Lai F, Luo JL, Jorgensen W, Ellison R, Gerona RR, Hibbs DE, McGregor IS, Glass M, Connor M, Bladen C, Zamponi GW, Banister SD . 6 . Putative Synthetic Cannabinoids MEPIRAPIM, 5F-BEPIRAPIM (NNL-2), and Their Analogues Are T-Type Calcium Channel (Ca_V3) Inhibitors . ACS Chemical Neuroscience . 13 . 9 . 1395–1409 . May 2022 . 35442021 . 10.1021/acschemneuro.1c00822 . 248264685 .
4. Web site: Cannabinoider föreslås bli klassade som hälsofarlig vara . 29 June 2015.