MEPE explained

Symbol:	Osteoregulin
Osteoregulin
Pfam:	PF07175
Interpro:	IPR009837

Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene.^{[1] [2]} A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.^[3]

Further reading

• Quarles LD . FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. . Am. J. Physiol. Endocrinol. Metab. . 285 . 1 . E1–9 . 2003 . 12791601 . 10.1152/ajpendo.00016.2003 .
• Ogbureke KU, Fisher LW . Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs). . Kidney Int. . 68 . 1 . 155–66 . 2005 . 15954904 . 10.1111/j.1523-1755.2005.00389.x . free .
• Ogbureke KU, Fisher LW . Expression of SIBLINGs and their partner MMPs in salivary glands. . J. Dent. Res. . 83 . 9 . 664–70 . 2004 . 15329369 . 10.1177/154405910408300902 . 17978869 .
• Jain A, Fedarko NS, Collins MT, etal . Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density. . J. Clin. Endocrinol. Metab. . 89 . 8 . 4158–61 . 2004 . 15292364 . 10.1210/jc.2003-032031 . free .
• Nampei A, Hashimoto J, Hayashida K, etal . Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. . J. Bone Miner. Metab. . 22 . 3 . 176–84 . 2005 . 15108058 . 10.1007/s00774-003-0468-9 . 13194013 .
• MacDougall M, Simmons D, Gu TT, Dong J . MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. . Connect. Tissue Res. . 43 . 2–3 . 320–30 . 2003 . 12489176 . 10.1080/713713461 .
• Argiro L, Desbarats M, Glorieux FH, Ecarot B . Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. . Genomics . 74 . 3 . 342–51 . 2001 . 11414762 . 10.1006/geno.2001.6553 .

Notes and References

1. Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL . MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia . Genomics . 67 . 1 . 54–68 . 1 July 2000 . 10945470 . 10.1006/geno.2000.6235 .
2. Web site: Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone).
3. Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA . Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes . J. Biol. Chem. . 275 . 46 . 36172–80 . November 2000 . 10967096 . 10.1074/jbc.M003622200 . free .