MAP2K1IP1 explained

Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.

Interactions

MAP2K1IP1 has been shown to interact with MAP2K1.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Okabe S, Tauchi T, Morita H, Ohashi H, Yoshimura A, Ohyashiki K . Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway . Exp. Hematol. . 27 . 10 . 1542–7 . 1999 . 10517496 . 10.1016/S0301-472X(99)00094-6 . free .
• Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA . A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment . J. Cell Biol. . 152 . 4 . 765–76 . 2001 . 11266467 . 2195784 . 10.1083/jcb.152.4.765 .
• Teis D, Wunderlich W, Huber LA . Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction . Dev. Cell . 3 . 6 . 803–14 . 2002 . 12479806 . 10.1016/S1534-5807(02)00364-7 . free .
• Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y . Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling . J. Biol. Chem. . 278 . 47 . 47089–97 . 2003 . 12975377 . 10.1074/jbc.M306002200 . free .
• Paces-Fessy M, Boucher D, Petit E, Paute-Briand S, Blanchet-Tournier MF . The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins . Biochem. J. . 378 . Pt 2 . 353–62 . 2004 . 14611647 . 1223961 . 10.1042/BJ20030786 .
• Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ . Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists . Proc. Natl. Acad. Sci. U.S.A. . 101 . 18 . 6981–6 . 2004 . 15118098 . 406452 . 10.1073/pnas.0305894101 . 2004PNAS..101.6981V . free .
• Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T . Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes . Proc. Natl. Acad. Sci. U.S.A. . 101 . 30 . 10984–9 . 2004 . 15263099 . 503730 . 10.1073/pnas.0403435101 . 2004PNAS..10110984K . free .
• Sharma C, Vomastek T, Tarcsafalvi A, Catling AD, Schaeffer HJ, Eblen ST, Weber MJ . MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling . J. Cell. Biochem. . 94 . 4 . 708–19 . 2005 . 15547943 . 10.1002/jcb.20344 . 19060718 .
• Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD . The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals . Mol. Cell. Biol. . 25 . 12 . 5119–33 . 2005 . 15923628 . 1140582 . 10.1128/MCB.25.12.5119-5133.2005 .
• Villegas SN, Njaine B, Linden R, Carri NG . Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways . Brain Res. Bull. . 71 . 1–3 . 116–26 . 2006 . 17113937 . 10.1016/j.brainresbull.2006.08.014 . 27498866 .
• Teis D, Taub N, Kurzbauer R, Hilber D, de Araujo ME, Erlacher M, Offterdinger M, Villunger A, Geley S, Bohn G, Klein C, Hess MW, Huber LA . p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis . J. Cell Biol. . 175 . 6 . 861–8 . 2006 . 17178906 . 2064696 . 10.1083/jcb.200607025 .
• Brahma A, Dalby KN . Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer . Arch. Biochem. Biophys. . 460 . 1 . 85–91 . 2007 . 17254543 . 2853909 . 10.1016/j.abb.2006.11.031 .
• Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ . RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility . Mol. Cell. Biol. . 27 . 23 . 8296–305 . 2007 . 17908799 . 2169169 . 10.1128/MCB.00598-07 .

Notes and References

1. Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ . MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade . Science . 281 . 5383 . 1668–71 . Oct 1998 . 9733512 . 10.1126/science.281.5383.1668 . 1998Sci...281.1668S .
2. Lunin VV, Munger C, Wagner J, Ye Z, Cygler M, Sacher M . The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling . J. Biol. Chem. . 279 . 22 . 23422–30 . May 2004 . 15016825 . 10.1074/jbc.M401648200 . free.
3. Web site: Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1.
4. Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA . A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment . J. Cell Biol. . 152 . 4 . 765–76 . Feb 2001 . 11266467 . 2195784 . 10.1083/jcb.152.4.765 .