MEIS2 explained

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.^{[1] [2]}

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.^[3]

Further reading

• Hui H, Perfetti R . Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood. . Eur. J. Endocrinol. . 146 . 2 . 129–41 . 2002 . 11834421 . 10.1530/eje.0.1460129 . free .
• Steelman S, Moskow JJ, Muzynski K, etal . Identification of a conserved family of Meis1-related homeobox genes. . Genome Res. . 7 . 2 . 142–56 . 1997 . 9049632 . 10.1101/gr.7.2.142 . free .
• Capdevila J, Tsukui T, Rodríquez Esteban C, etal . Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. . Mol. Cell . 4 . 5 . 839–49 . 2000 . 10619030 . 10.1016/S1097-2765(00)80393-7 . free .
• Yang Y, Hwang CK, D'Souza UM, etal . Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. . J. Biol. Chem. . 275 . 27 . 20734–41 . 2000 . 10764806 . 10.1074/jbc.M908382199 . free .
• Liu Y, MacDonald RJ, Swift GH . DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. . J. Biol. Chem. . 276 . 21 . 17985–93 . 2001 . 11279116 . 10.1074/jbc.M100678200 . free .
• Fujino T, Yamazaki Y, Largaespada DA, etal . Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. . Exp. Hematol. . 29 . 7 . 856–63 . 2001 . 11438208 . 10.1016/S0301-472X(01)00655-5 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Dintilhac A, Bihan R, Guerrier D, etal . A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis. . Gene Expr. Patterns . 4 . 2 . 215–22 . 2004 . 15161102 . 10.1016/j.modgep.2003.08.006 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Smith JE, Afonja O, Yee HT, Inghirami G, Takeshita K . Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene . Mamm Genome . 8 . 12 . 951–2 . Jan 1998 . 9383298 . 10.1007/s003359900621 . 20187903 .
2. Web site: Entrez Gene: MEIS2 Meis homeobox 2.
3. Web site: Entrez Gene: MEIS2 Meis homeobox 2.