MEGF10 explained

Multiple EGF-like-domains 10 is a protein that in humans is encoded by the MEGF10 gene.^[1]

MEGF10 is a regulator of satellite cell myogenesis and interacts with Notch1 in myoblasts.^[2] It has been shown to be the cause of early-onset myopathy, areflexia, respiratory distress and dysphagia.^[3]

MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells in mice. These cells are less likely to be near neighbours of the same subtype than would occur by chance, resulting in 'exclusion zones' that separate them. Mosaic arrangements provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.^[4]

Further reading

• Hamon Y, Trompier D, Ma Z, Venegas V, Pophillat M, Mignotte V, Zhou Z, Chimini G . Cooperation between engulfment receptors: the case of ABCA1 and MEGF10 . PLOS ONE . 1 . 1 . e120 . December 2006 . 17205124 . 1762421 . 10.1371/journal.pone.0000120 . 2006PLoSO...1..120H . Insall . Robert . free .
• Suzuki E, Nakayama M . The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern . Experimental Cell Research . 313 . 11 . 2451–64 . July 2007 . 17498693 . 10.1016/j.yexcr.2007.03.041 .
• Suzuki E, Nakayama M . MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation . Experimental Cell Research . 313 . 17 . 3729–42 . October 2007 . 17643423 . 10.1016/j.yexcr.2007.06.015 .
• Chen X, Wang X, Chen Q, Williamson V, van den Oord E, Maher BS, O'Neill FA, Walsh D, Kendler KS . MEGF10 association with schizophrenia . Biological Psychiatry . 63 . 5 . 441–8 . March 2008 . 18179784 . 2268016 . 10.1016/j.biopsych.2007.11.003 .
• Kang S, Zhao J, Liu Q, Zhou R, Wang N, Li Y . Vascular endothelial growth factor gene polymorphisms are associated with the risk of developing adenomyosis . Environmental and Molecular Mutagenesis . 50 . 5 . 361–6 . June 2009 . 19197986 . 10.1002/em.20455 . 2009EnvMM..50..361K . 27339435 .
• Chen X, Sun C, Chen Q, O'Neill FA, Walsh D, Fanous AH, Chowdari KV, Nimgaonkar VL, Scott A, Schwab SG, Wildenauer DB, Che R, Tang W, Shi Y, He L, Luo XJ, Su B, Edwards TL, Zhao Z, Kendler KS . Apoptotic engulfment pathway and schizophrenia . PLOS ONE . 4 . 9 . e6875 . September 2009 . 19721717 . 2731162 . 10.1371/journal.pone.0006875 . 2009PLoSO...4.6875C . Okazawa . Hitoshi . free .
• Yun L, Gu Y, Hou Y . No association between schizophrenia and rs27388 of the MEGF10 gene in Chinese case-control sample . Psychiatry Research . 186 . 2–3 . 467–8 . April 2011 . 20813413 . 10.1016/j.psychres.2010.08.002 . 207447640 .
• Singh TD, Park SY, Bae JS, Yun Y, Bae YC, Park RW, Kim IS . MEGF10 functions as a receptor for the uptake of amyloid-β . FEBS Letters . 584 . 18 . 3936–42 . September 2010 . 20828568 . 10.1016/j.febslet.2010.08.050 . 45140034 . free .

External links

• NCBI gene

Notes and References

1. Web site: Entrez Gene: Multiple EGF-like-domains 10. 2011-11-26 .
2. Saha M, Mitsuhashi S, Jones MD, Manko K, Reddy HM, Bruels C, Cho KA, Pacak CA, Draper I, Kang PB . Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions . Human Molecular Genetics . 26 . 15 . 2984–3000 . May 2017 . 28498977 . 6075367 . 10.1093/hmg/ddx189 .
3. Logan CV, Lucke B, Pottinger C, Abdelhamed ZA, Parry DA, Szymanska K, Diggle CP, van Riesen A, Morgan JE, Markham G, Ellis I, Manzur AY, Markham AF, Shires M, Helliwell T, Scoto M, Hübner C, Bonthron DT, Taylor GR, Sheridan E, Muntoni F, Carr IM, Schuelke M, Johnson CA . Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD) . Nature Genetics . 43 . 12 . 1189–92 . November 2011 . 22101682 . 10.1038/ng.995 . 5536249 .
4. Kay JN, Chu MW, Sanes JR . MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons . Nature . 483 . 7390 . 465–9 . March 2012 . 22407321 . 3310952 . 10.1038/nature10877 . 2012Natur.483..465K .