MEG8 explained

In molecular biology, Maternally expressed 8 (non-protein coding), also known as MEG8 or Rian (RNA Imprinted and Accumulated in Nucleus), is a long non-coding RNA. It is an imprinted gene, which is maternally expressed. It is expressed in the nucleus and (in an eight-week-old sheep) is preferentially expressed in skeletal muscle.^{[1] [2]}

See also

• Long noncoding RNA

Further reading

• Cavaillé J, Seitz H, Paulsen M, Ferguson-Smith AC, Bachellerie JP . Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region . Human Molecular Genetics . 11 . 13 . 1527–38 . June 2002 . 12045206 . 10.1093/hmg/11.13.1527 . free .

Notes and References

1. Hatada I, Morita S, Obata Y, Sotomaru Y, Shimoda M, Kono T . Identification of a new imprinted gene, Rian, on mouse chromosome 12 by fluorescent differential display screening . Journal of Biochemistry . 130 . 2 . 187–90 . August 2001 . 11481034 . 10.1093/oxfordjournals.jbchem.a002971 .
2. Charlier C, Segers K, Wagenaar D, Karim L, Berghmans S, Jaillon O, Shay T, Weissenbach J, Cockett N, Gyapay G, Georges M . 6 . Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8 . Genome Research . 11 . 5 . 850–62 . May 2001 . 11337479 . 311092 . 10.1101/gr.172701 .