MEF2D explained

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.^{[1] [2]}

Interactions

MEF2D has been shown to interact with:

• CABIN1,^[3]
• EP300,^{[4] [5]}
• MAPK7,^[6]
• Myocyte-specific enhancer factor 2A,^[7]
• NFATC2^[8]
• Sp1 transcription factor,^[9] and
• YWHAQ.^[10]

See also

• Mef2

Further reading

• Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL . Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23 . Genomics . 29 . 3 . 704–711 . Oct 1995 . 8575763 . 10.1006/geno.1995.9007 .
• Ornatsky OI, McDermott JC . MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells . The Journal of Biological Chemistry . 271 . 40 . 24927–24933 . Oct 1996 . 8798771 . 10.1074/jbc.271.40.24927 . free .
• Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA . Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1 . Nucleic Acids Research . 26 . 20 . 4771–4777 . Oct 1998 . 9753748 . 147902 . 10.1093/nar/26.20.4771 .
• Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J . Regulation of the MEF2 family of transcription factors by p38 . Molecular and Cellular Biology . 19 . 1 . 21–30 . Jan 1999 . 9858528 . 83862 . 10.1128/mcb.19.1.21 .
• Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ . HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor . Molecular and Cellular Biology . 19 . 11 . 7816–7827 . Nov 1999 . 10523670 . 84849 . 10.1128/mcb.19.11.7816 .
• Lu J, McKinsey TA, Nicol RL, Olson EN . Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases . Proceedings of the National Academy of Sciences of the United States of America . 97 . 8 . 4070–4075 . Apr 2000 . 10737771 . 18151 . 10.1073/pnas.080064097 . 2000PNAS...97.4070L . free .
• Kato Y, Zhao M, Morikawa A, Sugiyama T, Chakravortty D, Koide N, Yoshida T, Tapping RI, Yang Y, Yokochi T, Lee JD . Big mitogen-activated kinase regulates multiple members of the MEF2 protein family . The Journal of Biological Chemistry . 275 . 24 . 18534–18540 . Jun 2000 . 10849446 . 10.1074/jbc.M001573200 . free .
• Youn HD, Chatila TA, Liu JO . Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis . The EMBO Journal . 19 . 16 . 4323–4331 . Aug 2000 . 10944115 . 302027 . 10.1093/emboj/19.16.4323 .
• Slepak TI, Webster KA, Zang J, Prentice H, O'Dowd A, Hicks MN, Bishopric NH . Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D . The Journal of Biological Chemistry . 276 . 10 . 7575–7585 . Mar 2001 . 11096067 . 10.1074/jbc.M004625200 . free .
• Choi SJ, Park SY, Han TH . 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation . Nucleic Acids Research . 29 . 13 . 2836–2842 . Jul 2001 . 11433030 . 55772 . 10.1093/nar/29.13.2836 .
• Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA . Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis . Proceedings of the National Academy of Sciences of the United States of America . 99 . 6 . 3974–3979 . Mar 2002 . 11904443 . 122633 . 10.1073/pnas.022036399 . 2002PNAS...99.3974O . free .
• Park SY, Shin HM, Han TH . Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter . Molecular Immunology . 39 . 1–2 . 25–30 . Sep 2002 . 12213324 . 10.1016/S0161-5890(02)00055-X .
• Linseman DA, Bartley CM, Le SS, Laessig TA, Bouchard RJ, Meintzer MK, Li M, Heidenreich KA . Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival . The Journal of Biological Chemistry . 278 . 42 . 41472–41481 . Oct 2003 . 12896970 . 10.1074/jbc.M307245200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–12135 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Grégoire S, Yang XJ . Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors . Molecular and Cellular Biology . 25 . 6 . 2273–2287 . Mar 2005 . 15743823 . 1061617 . 10.1128/MCB.25.6.2273-2287.2005 .
• Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP . Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia . Leukemia . 19 . 5 . 806–813 . May 2005 . 15744350 . 10.1038/sj.leu.2403684 . free .

Notes and References

1. Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B . A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage . Development . 118 . 4 . 1095–1106 . Aug 1993 . 10.1242/dev.118.4.1095 . 8269842 .
2. Web site: Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D).
3. Youn HD, Sun L, Prywes R, Liu JO . Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 . Science . 286 . 5440 . 790–793 . Oct 1999 . 10531067 . 10.1126/science.286.5440.790.
4. Youn HD, Grozinger CM, Liu JO . Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4 . The Journal of Biological Chemistry . 275 . 29 . 22563–22567 . Jul 2000 . 10825153 . 10.1074/jbc.C000304200 . free .
5. Youn HD, Liu JO . Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 . Immunity . 13 . 1 . 85–94 . Jul 2000 . 10933397 . 10.1016/s1074-7613(00)00010-8. free .
6. Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA . Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1 . Nucleic Acids Research . 26 . 20 . 4771–4777 . Oct 1998 . 9753748 . 147902 . 10.1093/nar/26.20.4771.
7. Ornatsky OI, McDermott JC . MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells . The Journal of Biological Chemistry . 271 . 40 . 24927–24933 . Oct 1996 . 8798771 . 10.1074/jbc.271.40.24927. free .
8. Youn HD, Chatila TA, Liu JO . Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis . The EMBO Journal . 19 . 16 . 4323–4331 . Aug 2000 . 10944115 . 302027 . 10.1093/emboj/19.16.4323 .
9. Park SY, Shin HM, Han TH . Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter . Molecular Immunology . 39 . 1–2 . 25–30 . Sep 2002 . 12213324 . 10.1016/s0161-5890(02)00055-x.
10. Choi SJ, Park SY, Han TH . 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation . Nucleic Acids Research . 29 . 13 . 2836–2842 . Jul 2001 . 11433030 . 55772 . 10.1093/nar/29.13.2836.