MED4 explained

Symbol:	Med4
Med4
Pfam:	PF10018
Interpro:	IPR019258

Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a component of the vitamin D receptor-interacting protein (DRIP) complex which functions as a nuclear receptor coactivator. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent manner.^[2]

Interactions

MED4 has been shown to interact with MED25.^[4]

Further reading

• Conaway JW, Florens L, Sato S, Tomomori-Sato C, Parmely TJ, Yao T, Swanson SK, Banks CA, Washburn MP, Conaway RC . The mammalian Mediator complex. . FEBS Lett. . 579 . 4 . 904–8 . 2005 . 15680972 . 10.1016/j.febslet.2004.11.031 . 45924145 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG . Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. . Mol. Cell . 3 . 3 . 361–70 . 1999 . 10198638 . 10.1016/S1097-2765(00)80463-3 . free .
• Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP . Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. . Nature . 398 . 6730 . 824–8 . 1999 . 10235266 . 10.1038/19783 . 1999Natur.398..824R . 204992765 .
• Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R . Composite co-activator ARC mediates chromatin-directed transcriptional activation. . Nature . 398 . 6730 . 828–32 . 1999 . 10235267 . 10.1038/19789 . 1999Natur.398..828N . 23646963 .
• Malik S, Gu W, Wu W, Qin J, Roeder RG . The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. . Mol. Cell . 5 . 4 . 753–60 . 2000 . 10882111 . 10.1016/S1097-2765(00)80254-3 . free .
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 310934 . 10.1101/gr.140200 .

Notes and References

1. Web site: Entrez Gene: MED4 mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae).
2. Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP . Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex . Nature . 398 . 6730 . 824–8 . April 1999 . 10235266 . 10.1038/19783 . 1999Natur.398..824R . 204992765 .
3. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Research . 10 . 10 . 1546–60 . October 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
4. Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW . A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 . J. Biol. Chem. . 279 . 7 . 5846–51 . Feb 2004 . 14638676 . 10.1074/jbc.M312523200 . free .