MED29 explained

Symbol:	Med29
Med29
Pfam:	PF11568
Interpro:	IPR021018

Mediator of RNA polymerase II transcription subunit 29 (Med29) is a transcription suppressor that in humans is encoded by the MED29 gene.^[1] It represents subunit MED29 of the Mediator complex.

Med29, along with Med11 and Med28 in mammals, is part of the core head-region of the Mediator complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein (IXL), which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.^[2]

See also

• Mediator

Notes and References

1. Wang Y, Li Y, Zeng W, Zhu C, Xiao J, Yuan W, etal . IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor. . Biochem Biophys Res Commun . 2004 . 325 . 4 . 1330–8 . 15555573 . 10.1016/j.bbrc.2004.10.159 .
2. Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW . The mammalian Mediator complex and its role in transcriptional regulation . Trends Biochem. Sci. . 30 . 5 . 250–5 . May 2005 . 15896743 . 10.1016/j.tibs.2005.03.002 .