MED25 explained

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.^{[1] [2] [3]}

Interactions

MED25 has been shown to interact with MED4.^[4]

Further reading

• Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R . Composite co-activator ARC mediates chromatin-directed transcriptional activation . Nature . 398 . 6730 . 828–32 . Apr 1999 . 10235267 . 10.1038/19789 . 1999Natur.398..828N . 23646963 .
• Wang C, McCarty IM, Balazs L, Li Y, Steiner MS . A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein . Biochemical and Biophysical Research Communications . 296 . 2 . 281–7 . Aug 2002 . 12163014 . 10.1016/S0006-291X(02)00872-0 .
• Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW . A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex . The Journal of Biological Chemistry . 278 . 50 . 49671–4 . Dec 2003 . 14576168 . 10.1074/jbc.C300444200 . free .
• Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW . A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 . The Journal of Biological Chemistry . 279 . 7 . 5846–51 . Feb 2004 . 14638676 . 10.1074/jbc.M312523200 . free .
• Mittler G, Stühler T, Santolin L, Uhlmann T, Kremmer E, Lottspeich F, Berti L, Meisterernst M . A novel docking site on Mediator is critical for activation by VP16 in mammalian cells . The EMBO Journal . 22 . 24 . 6494–504 . Dec 2003 . 14657022 . 291814 . 10.1093/emboj/cdg619 .
• Yang F, DeBeaumont R, Zhou S, Näär AM . The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator . Proceedings of the National Academy of Sciences of the United States of America . 101 . 8 . 2339–44 . Feb 2004 . 14983011 . 356952 . 10.1073/pnas.0308676100 . 2004PNAS..101.2339Y . free .
• Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC . A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology . Molecular Cell . 14 . 5 . 685–91 . Jun 2004 . 15175163 . 10.1016/j.molcel.2004.05.006 . free .
• Zhang X, Krutchinsky A, Fukuda A, Chen W, Yamamura S, Chait BT, Roeder RG . MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription . Molecular Cell . 19 . 1 . 89–100 . Jul 2005 . 15989967 . 10.1016/j.molcel.2005.05.015 . free .
• Lee HK, Park UH, Kim EJ, Um SJ . MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation . The EMBO Journal . 26 . 15 . 3545–57 . Aug 2007 . 17641689 . 1949011 . 10.1038/sj.emboj.7601797 .

External links

• GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2

Notes and References

1. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . Apr 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . Mar 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
3. Web site: Entrez Gene: MED25 mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae).
4. Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW . A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 . The Journal of Biological Chemistry . 279 . 7 . 5846–51 . Feb 2004 . 14638676 . 10.1074/jbc.M312523200 . free .