MED22 explained

Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.^{[1] [2] [3]}

Function

This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.

Interactions

MED22 has been shown to interact with MED30.^[4]

Further reading

• De Falco S, Russo G, Angiolillo A, Pietropaolo C . Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene . Gene . 126 . 2 . 227–35 . Apr 1993 . 8482538 . 10.1016/0378-1119(93)90371-9 .
• Garson K, Duhig T, Armes N, Colombo P, Fried M . Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene . Genomics . 30 . 2 . 163–70 . Nov 1995 . 8586415 . 10.1006/geno.1995.9889 .
• Garson K, Duhig T, Fried M . Tissue-specific processing of the Surf-5 and Surf-4 mRNAs . Gene Expression . 6 . 4 . 209–18 . 1997 . 9196076 . 6148271 .
• Duhig T, Ruhrberg C, Mor O, Fried M . The human Surfeit locus . Genomics . 52 . 1 . 72–8 . Aug 1998 . 9740673 . 10.1006/geno.1998.5372 .
• Angiolillo A, Russo G, Porcellini A, Smaldone S, D'Alessandro F, Pietropaolo C . The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts . Gene . 284 . 1–2 . 169–78 . Feb 2002 . 11891058 . 10.1016/S0378-1119(02)00379-7 .
• Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW . Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 . The Journal of Biological Chemistry . 278 . 17 . 15123–7 . Apr 2003 . 12584197 . 10.1074/jbc.C300054200 . free .
• Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW . A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex . The Journal of Biological Chemistry . 278 . 50 . 49671–4 . Dec 2003 . 14576168 . 10.1074/jbc.C300444200 . free .
• Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW . A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 . The Journal of Biological Chemistry . 279 . 7 . 5846–51 . Feb 2004 . 14638676 . 10.1074/jbc.M312523200 . free .
• Hillman RT, Green RE, Brenner SE . An unappreciated role for RNA surveillance . Genome Biology . 5 . 2 . R8 . 2005 . 14759258 . 395752 . 10.1186/gb-2004-5-2-r8 . free .

Notes and References

1. Yon J, Jones T, Garson K, Sheer D, Fried M . The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1 . Human Molecular Genetics . 2 . 3 . 237–40 . Mar 1993 . 8499913 . 10.1093/hmg/2.3.237 .
2. Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC . A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology . Molecular Cell . 14 . 5 . 685–91 . Jun 2004 . 15175163 . 10.1016/j.molcel.2004.05.006 . free .
3. Web site: Entrez Gene: SURF5 surfeit 5.
4. Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW . Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 . The Journal of Biological Chemistry . 278 . 17 . 15123–7 . Apr 2003 . 12584197 . 10.1074/jbc.C300054200 . free .