MEAI explained

MEAI (5-methoxy-2-aminoindane or 5-MeO-AI or Chaperon) belongs to the indane family of molecules. Its molecular structure was first mentioned implicitly in a markush structure schema appearing in a patent from 1998.[1] It was later explicitly and pharmacologically described in a peer reviewed paper in 2017 by David Nutt and Ezekiel Golan et al.[2] followed by another in February 2018 which detailed the pharmacokinetics, pharmacodynamics and metabolism of MEAI by Shimshoni, David Nutt, Ezekiel Golan et al.[3] One year later it was studied and reported on in another peer reviewed paper by Halberstadt et al.[4] The aminoindane family of molecules was, perhaps, first chemically described in 1980.[5] [6]

MEAI was an early candidate of alcohol replacement drugs that came to market during a late 2010s movement to replace alcohol with less-toxic alternatives spearheaded by British psychopharmacologist David Nutt[7] [8] [9] rippling to the rest of Europe.[10]

In an act of gonzo journalism, Michael Slezak writing for New Scientist, tried and reported on his experience with MEAI after being provided with it by Dr Zee[11] (Ezekiel Golan) after an interview[12] Golan claimed he invented MEAI and originally intended MEAI to be sold as a legal high but instead indicated plans to work with David Nutt and his company DrugScience to develop MEAI further based on Golan's patents as a "binge behaviour regulator"[13] and "alcoholic beverage substitute".[14]

On May 26, 2022, MEAI was prepared for FDA registration by Clearmind Medicine Inc.;[21] [22] [23] Clearmind Medicine claims wide intellectual property holdings to Ezekiel Golan's patents.[24] [25] [26] [27] In March 2022 Clearmind Medicine announced supportive evidence from animal studies in mice attesting to suppression of alcohol consumption.[28] In June 2022 Clearmind Medicine announced promising results from animal studies that showed promise for treating cocaine addiction with MEAI.[29] [30]

See also

External links

Notes and References

  1. US. 5708018. 2-aminoindans as selective dopamine D3 ligands. 1998-01-13. Haadsma-Svensson SR, Andersson BR, Sonesson CA, Lin CH, Waters RN, Svensson KA, Carlsson PA, Hansson LO, Stjernlof NP . Pharmacia & Upjohn Co..
  2. Shimshoni JA, Winkler I, Edery N, Golan E, van Wettum R, Nutt D . Toxicological evaluation of 5-methoxy-2-aminoindane (MEAI): Binge mitigating agent in development . Toxicology and Applied Pharmacology . 319 . 59–68 . March 2017 . 28167221 . 10.1016/j.taap.2017.01.018 . 205304106 .
  3. Shimshoni JA, Sobol E, Golan E, Ben Ari Y, Gal O . Pharmacokinetic and pharmacodynamic evaluation of 5-methoxy-2-aminoindane (MEAI): A new binge-mitigating agent . Toxicology and Applied Pharmacology . 343 . 29–39 . March 2018 . 29458138 . 10.1016/j.taap.2018.02.009 . 3879333 .
  4. Halberstadt AL, Brandt SD, Walther D, Baumann MH . 2-Aminoindan and its ring-substituted derivatives interact with plasma membrane monoamine transporters and α2-adrenergic receptors . Psychopharmacology . 236 . 3 . 989–999 . March 2019 . 30904940 . 6848746 . 10.1007/s00213-019-05207-1 .
  5. Sainsbury PD, Kicman AT, Archer RP, King LA, Braithwaite RA . Aminoindanes--the next wave of 'legal highs'? . Drug Testing and Analysis . 3 . 7–8 . 479–482 . 2011 . 21748859 . 10.1002/dta.318 .
  6. Cannon JG, Perez JA, Pease JP, Long JP, Flynn JR, Rusterholz DB, Dryer SE . Comparison of biological effects of N-alkylated congeners of beta-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene . Journal of Medicinal Chemistry . 23 . 7 . 745–749 . July 1980 . 7190613 . 10.1021/jm00181a009 .
  7. Web site: Nutt D . Decision making about illegal drugs: time for science to take the lead . Nobel Forum, Karolinska Institutet . 23 October 2013 . . en.
  8. Nutt DJ, King LA, Phillips LD . Drug harms in the UK: a multicriteria decision analysis . Lancet . London, England . 376 . 9752 . 1558–65 . November 2010 . 21036393 . 10.1016/S0140-6736(10)61462-6 . 5667719 .
  9. News: Forster K . Hangover free alcohol is finally here . 25 March 2022 . The Independent . 24 September 2016 . en.
  10. Web site: Rauschmittel und gesellschaftliche Probleme . Drug related societal issues . Benedict Wermter . Wermter B . de-DE . 29 April 2019.
  11. News: Slezak M . 9 August 2014 . An Interview with Dr Z . 1–3 . New Scientist . 16 October 2022.
  12. Web site: Slezak M . 30 December 2014 . High and dry? Party drug could target excess drinking . 2022-10-16 . New Scientist . en-US.
  13. US . 10406123B2. Binge behavior regulators. 2019-09-10. Golan E .
  14. US . 20170360067 . Alcoholic beverage substitutes . 2017-12-21 . Golan E .
  15. Web site: Advisory - Health Canada warns consumers that Pace, promoted as an alcohol substitute, is unauthorized and may pose serious health risks . Health Canada . CISION . 21 December 2018 .
  16. Web site: Brunet J . 24 April 2019 . FACT CHECK: Is Pace, an "Alcohol Alternative," Legal in Canada? . The Walrus . Toronto, Ontario .
  17. News: Wright J . 8 December 2018 . Is this drink really a new 'alcohol alternative'? . All . Information Morning Saint John . 15 October 2022.
  18. Web site: Extance A . 6 September 2017 . The rising tide of 'legal highs' . 2022-10-17 . Chemistry World . en.
  19. Web site: 23 January 2018 . Meet Dr. Zee - the man who invented legal highs . BBC .
  20. Web site: Jonze T . 24 May 2016 . Dr Zee, the godfather of legal highs: 'I test everything on myself' . TheGuardian.com.
  21. Web site: Clearmind Medicine . www.clearmindmedicine.com.
  22. Web site: Clearmind Medicine Inc. . CSE:CMND .
  23. News: החברה שמנסה להפוך סם פסיכדלי למוצר נגד התמכרות . The company trying to turn a psychedelic drug into an anti-addiction product . Globes . 16 February 2022 . Hebrew . וינרב . גלי .
  24. US. 10137096. 2018-11-27. Binge behavior regulators. Golan E .
  25. EP. 3230256. 2019-11-13. Alcoholic beverage substitutes. Golan E .
  26. EP. 3230255. 2017-10-18. Binge behavior regulators. Golan E .
  27. Web site: The Science and IP Behind our Treatments . Clearmind .
  28. Web site: Clearmind Medicine . www.clearmindmedicine.com.
  29. Web site: Clearmind Medicine . www.clearmindmedicine.com . 14 August 2022.
  30. Web site: Clearmind Medicine . 2022-10-16 . www.clearmindmedicine.com.

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