MDPHP explained

MDPHP (3',4'-Methylenedioxy-α-pyrrolidinohexiophenone) is a stimulant of the cathinone class originally developed in the 1960s,[1] which has been reported as a novel designer drug. In the UK its slang name is monkey dust.[2] [3] It is closely related to the potent stimulant MDPV though with slightly milder effects, and has been used as an alternative in some countries following the banning of MDPV.[4] [5] [6] [7]

Pharmacology

MDPHP acts as a potent norepinephrine-dopamine reuptake inhibitor. The IC50 values for MDPHP are 0.06 μM at NET, 0.05 μM at DAT and 9 μM at SERT.[8]

Legal status

MDPHP is specifically listed as a controlled substance in Japan [9] and Hungary,[10] and is controlled under analogue provisions in a number of other jurisdictions.

Documented fatalities

A case of a "fatal acute intoxication caused by MDPHP" in a 48 year old male was reported in February 2022 by physicians at an Italian hospital.[11] Another case has been reported, involving a 30-years-old male cocaine consumer, found dead on July 20th, 2023, in Florence, Italy; MDPHP and alpha-PHP were the only psychoactive substance found. [12]

See also

Notes and References

  1. DE . 1545591 . Koeppe H, Zeile K, Ludwig G . Patent DE - Verfahren zur Herstellung von α-Aminoketonen mit heterocyclischer Aminogruppe . 28 May 1965.
  2. Web site: Monkey Dust drug use 'an epidemic', emergency workers warn . . 10 August 2018 . 16 August 2018.
  3. https://www.bbc.com/news/health-65556046 Roberts M. Monkey dust drug clampdown could be coming in UK. BBC News, 11 May 2023
  4. Zaitsu K, Katagi M, Tsuchihashi H, Ishii A . 25604845. 10.1007/s11419-013-0218-1. Recently abused synthetic cathinones, α-pyrrolidinophenone derivatives: A review of their pharmacology, acute toxicity, and metabolism. Forensic Toxicology. 32. 1–8. 2013 .
  5. Kaizaki-Mitsumoto A, Noguchi N, Yamaguchi S, Odanaka Y, Matsubayashi S, Kumamoto H, Fukuhara K, Funada M, Wada K, Numazawa S . 45890497 . 6 . Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34, and escaline), eight cathinone derivatives, and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market. . Forensic Toxicology . January 2016 . 34 . 1 . 108–14 . 10.1007/s11419-015-0293-6 .
  6. Beck O, Bäckberg M, Signell P, Helander A . 3401681 . Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats . Clinical Toxicology . Philadelphia, Pa. . 56 . 4 . 256–263 . April 2018 . 28895757 . 10.1080/15563650.2017.1370097 . free .
  7. Fowble KL, Shepard JR, Musah RA . Identification and classification of cathinone unknowns by statistical analysis processing of direct analysis in real time-high resolution mass spectrometry-derived "neutral loss" spectra . Talanta . 179 . 546–553 . March 2018 . 29310273 . 10.1016/j.talanta.2017.11.020 . free .
  8. Kolaczynska K, Thomann J, Hoener M, Liechti M . The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative . International Journal of Molecular Sciences . 2021 . 22 . 15 . 8277 . 10.3390/ijms22158277 . free . 34361040. 8348686 .
  9. Web site: 指定薬物名称・構造式一覧（平成27年9月16日現在）. List of designated drug names and structural formulas (as of September 16, 2015) . 厚生労働省 (Ministry of Health, Labour and Welfare) . 16 September 2015 . Japanese . 8 October 2015.
  10. Web site: A Daath.hu kiegészítése a BSZKI "designer jogi listáján" nem szereplő, de a C-lista 1.-4. szerkezeti leírásainak megfelelő, illetve a C-lista 5. felsorolásában szereplő néhány anyagról . The addition to Daath.hu is not included in the "designer legal list" of the BSZKI, but C-list 1.-4. and some of the substances in list 5 of list C. . Hungarian .
  11. Di Candia D, Boracchi M, Ciprandi B, Giordano G, Zoja R . A unique case of death by MDPHP with no other co-ingestion: a forensic toxicology case . International Journal of Legal Medicine . 136 . 5 . 1291–1296 . September 2022 . 35169902 . 9375735 . 10.1007/s00414-022-02799-w .
  12. NEWS-D "NEWS-D_16_24_Allerta di grado 3_decesso_MDPHP" July 16th, 2024 by the National Early Warning System on Drugs

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