MDMB-CHMINACA explained

MDMB-CHMINACA[1] (also known as MDMB(N)-CHM) is an indazole-based synthetic cannabinoid that acts as a potent agonist of the CB1 receptor,[2] and has been sold online as a designer drug.[3] [4] [5] [6] [7] It was invented by Pfizer in 2008, and is one of the most potent cannabinoid agonists known, with a binding affinity of 0.0944 nM at CB1, and an EC50 of 0.330 nM.[8] It is closely related to MDMB-FUBINACA, which caused at least 1000 hospitalizations and 40 deaths in Russia as consequence of intoxication.[9]

Legal status

MDMB-CHMINACA is a Fifth Schedule of the Misuse of Drugs Act (MDA) controlled substance in Singapore as of May 2015.[10]

MDMB-CHMINACA is illegal in Germany, Switzerland as of December 2015.[11]

Sweden's public health agency suggested classifying MDMB-CHMINACA as a hazardous substance, on September 25, 2019.[12]

See also

Notes and References

  1. Pulver B, Fischmann S, Gallegos A, Christie R . EMCDDA framework and practical guidance for naming synthetic cannabinoids . Drug Testing and Analysis . 15 . 3 . 255–276 . March 2023 . 36346325 . 10.1002/dta.3403 .
  2. Banister SD, Longworth M, Kevin R, Sachdev S, Santiago M, Stuart J, Mack JB, Glass M, McGregor IS, Connor M, Kassiou M . Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues . ACS Chemical Neuroscience . 7 . 9 . 1241–54 . September 2016 . 27421060 . 10.1021/acschemneuro.6b00137 .
  3. Web site: MDMB-CHMINACA . Cayman Chemical . 14 July 2015.
  4. Shevyrin V, Melkozerov V, Nevero A, Eltsov O, Shafran Y, Morzherin Y, Lebedev AT . Identification and analytical characteristics of synthetic cannabinoids with an indazole-3-carboxamide structure bearing a N-1-methoxycarbonylalkyl group . Analytical and Bioanalytical Chemistry . 407 . 21 . 6301–15 . August 2015 . 25893797 . 10.1007/s00216-015-8612-7 . 31838655 .
  5. Web site: Detection methods of psychoactive substances and liquid chromotograoghy detection of metabolites. . Russian Ministry of Health . 2014 . 14 July 2015 . Savchuk SA . ru.
  6. Web site: Идентификация синтетических каннабимиметиков MDMB-CHMINACA, MDMB-FUBINACA и их метаболитов . Identification of synthetic cannabimimetics MDMB-CHMINACA, MDMB-FUBINACA and their metabolites . CTS "SCIENCE" . 14 July 2015. ru.
  7. Hess C, Murach J, Krueger L, Scharrenbroch L, Unger M, Madea B, Sydow K . Simultaneous detection of 93 synthetic cannabinoids by liquid chromatography-tandem mass spectrometry and retrospective application to real forensic samples . Drug Testing and Analysis . 9 . 5 . 721–733 . May 2017 . 27400642 . 10.1002/dta.2030 .
  8. http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2009106980 Buchler IP et al, INDAZOLE DERIVATIVES. WO 2009/106980
  9. Web site: Очередная жертва спайса . Another victim of spice . Federal Drug Control Service of the Russian Federation . 17 March 2015 . 13 July 2015 . ru . https://web.archive.org/web/20150714044651/http://www.fskn.gov.ru/includes/periodics/news/2015/0317/205035975/detail.shtml . 14 July 2015 . dead .
  10. Web site: CNB NEWS RELEASE . Central Narcotics Bureau (CNB) . 30 April 2015 . 14 July 2015 . https://web.archive.org/web/20150715045305/http://www.cnb.gov.sg/Libraries/CNB_Newsroom_Files/CNB_NR_-_30_Apr_2015.sflb.ashx . 15 July 2015 . dead .
  11. Web site: Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien . Der Bundesrat. de.
  12. Web site: Tretton ämnen föreslås klassas som narkotika eller hälsofarlig vara . Thirteen substances are proposed to be classified as narcotics or dangerous goods . Folkhälsomyndigheten (The Public Health Authority) . sv . 25 September 2019 .

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