MDMB-5Br-INACA explained

MDMB-5Br-INACA is an indazole-3-carboxamide derivative which has been sold as a designer drug.^[1] Surprisingly it appears to produce psychoactive activity despite the lack of a "tail" group at the indazole 1-position, but is of relatively low potency and has been encountered being misrepresented as other illicit drugs such as MDMA.^{[2] [3]}

Use as a precursor

MDMB-5Br-INACA is believed to be used as a precursor in the synthesis of synthetic cannabinoids. It has been sold online as "half finished" synthetic cannabinoids, sometimes as a "chemistry kit" with other compounds required to complete the reaction. This reaction would complete MDMB-5Br-INACA by giving it a "tail" group required for high cannabinoid activity. Other precursors lacking a tail chain have also been marketed such as (ADB-5-Br-INACA),^[4] (CH-IATA), (ADB-IACA), and (ADB-5’Br-EZO-CA). This may be due to increasing legality changes worldwide on synthetic cannabinoids.^{[5] [6]}

Legality

In the United States, MDMB-5Br-INACA is unscheduled at the federal level as of May 22nd, 2023.

North Dakota has placed MDMB-5Br-INACA (along with ADB-5'Br-BINACA, ADB-5'Br-BUTINACA and ADB-5-Br-INACA) into Schedule I on 04/27/2023.^[7]

See also

• 4F-MDMB-BINACA
• 5F-ADB
• ADB-5'Br-PINACA
• MDMB-FUBINACA
• MDMB-5'Br-BUTINACA

Notes and References

1. Web site: CFSRE Analysis Report . Indianapolis-Marion County Forensic Services Agency . 17 May 2022 .
2. Web site: Drug testers warn of new synthetic cannabinoid being sold as MDMA . New Zealand Herald . 5 August 2022 .
3. Deventer MH, Persson M, Norman C, Liu H, Connolly MJ, Daéid NN, McKenzie C, Gréen H, Stove CP . In vitro cannabinoid activity profiling of generic ban-evading brominated synthetic cannabinoid receptor agonists and their analogs . Drug Testing and Analysis . October 2023 . 37903509 . 10.1002/dta.3592 . 264671035 .
4. Choi H, Kim S, Jang H, Kim HJ, Choe S . Identification of a novel bromoindazole synthetic cannabinoid analogue in seized e-cigarette liquid: ADB-BRINACA . Forensic Science International . 338 . 111385 . September 2022 . 35863161 . 10.1016/j.forsciint.2022.111385 .
5. Web site: Cumyl-PeGaClone and other recently encountered synthetic cannabinoid receptor agonists. A review of the evidence on their use and harms. . Advisory Council on the Misuse of Drugs . 2022 .
6. Andrews R, Jorge R, Christie R, Gallegos A . From JWH-018 to OXIZIDS: Structural evolution of synthetic cannabinoids in the European Union from 2008 to present day . Drug Testing and Analysis . 15 . 4 . 378–387 . April 2023 . 36507715 . 10.1002/dta.3422 .
7. Web site: AN ACT to amend and reenact sections 19-03.1-05, 19-03.1-11, and 19-03.1-13 of the North Dakota Century Code, relating to the scheduling of controlled substances; and to declare an emergency. . Sixty-eighth Legislative Assembly of North Dakota in Regular Session . 3 January 2023 .