MCT-1 explained

MCTS1, re-initiation and release factor, otherwise known as MCT-1, is a protein that in humans is encoded by the MCTS1 gene.^[1]

See also

• Eukaryotic translation
• Eukaryotic initiation factor

Further reading

• Shi B, Hsu HL, Evens AM, Gordon LI, Gartenhaus RB . Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies . Blood . 102 . 1 . 297–302 . 2003 . 12637315 . 10.1182/blood-2002-11-3486 .
• Shi B, Levenson V, Gartenhaus RB . Identification and characterization of a novel enhancer for the human MCT-1 oncogene promoter . J. Cell. Biochem. . 90 . 1 . 68–79 . 2003 . 12938157 . 10.1002/jcb.10609 . 31678534 .
• Mazan-Mamczarz K, Hagner P, Dai B, Corl S, Liu Z, Gartenhaus RB . Targeted suppression of MCT-1 attenuates the malignant phenotype through a translational mechanism . Leuk. Res. . 33 . 3 . 474–82 . 2009 . 18824261 . 10.1016/j.leukres.2008.08.012 .
• Kasiappan R, Shih HJ, Chu KL, Chen WT, Liu HP, Huang SF, Choy CO, Shu CL, Din R, Chu JS, Hsu HL . Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity . Mol. Cancer Res. . 7 . 4 . 536–48 . 2009 . 19372582 . 10.1158/1541-7786.MCR-08-0422 . free .
• Pérez-Arellano I, Gozalbo-Rovira R, Martínez AI, Cervera J . Expression and purification of recombinant human MCT-1 oncogene in insect cells . Protein J. . 29 . 2 . 69–74 . 2010 . 20076993 . 10.1007/s10930-009-9223-y . 5299658 .
• Chen H, Wang L, Beretov J, Hao J, Xiao W, Li Y . Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression . Clin. Exp. Metastasis . 27 . 8 . 557–69 . 2010 . 20658178 . 10.1007/s10585-010-9345-9 . 26525740 .
• Narumi K, Furugen A, Kobayashi M, Otake S, Itagaki S, Iseki K . Regulation of monocarboxylate transporter 1 in skeletal muscle cells by intracellular signaling pathways . Biol. Pharm. Bull. . 33 . 9 . 1568–73 . 2010 . 20823576 . 10.1248/bpb.33.1568. free .
• Kasiappan R, Shih HJ, Wu MH, Choy C, Lin TD, Chen L, Hsu HL . The antagonism between MCT-1 and p53 affects the tumorigenic outcomes . Mol. Cancer . 9 . 311 . 2010 . 21138557 . 3019166 . 10.1186/1476-4598-9-311 . free .
• Shih HJ, Chu KL, Wu MH, Wu PH, Chang WW, Chu JS, Wang LH, Takeuchi H, Ouchi T, Hsu HL . The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities . Cell Cycle . 11 . 5 . 934–52 . 2012 . 22336915 . 10.4161/cc.11.5.19452 . free .

Notes and References

1. Web site: Entrez Gene: MCTS1, re-initiation and release factor. 2018-01-01.